Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0040-4039(99)01050-3
Title: Solution-phase parallel oxazole synthesis with TosMIC
Authors: Kulkarni, B.A. 
Ganesan, A. 
Keywords: Combinatorial chemistry
Isocyanides
Oxazoles
Supported reagents/reactions
Issue Date: Jul-1999
Citation: Kulkarni, B.A., Ganesan, A. (1999-07). Solution-phase parallel oxazole synthesis with TosMIC. Tetrahedron Letters 40 (30) : 5637-5638. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(99)01050-3
Abstract: A quaternary ammonium hydroxide ion exchange resin catalyzes the reaction of p-tolylsulfonylmethyl isocyanide (TosMIC) with aromatic aldehydes to give 5-aryloxazoles. The base and the p-tolylsulfinic acid byproduct are removed by simple filtration, resulting in oxazoles in high yield and purity.
Source Title: Tetrahedron Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/112080
ISSN: 00404039
DOI: 10.1016/S0040-4039(99)01050-3
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