Please use this identifier to cite or link to this item: https://doi.org/10.2217/fon.12.25
Title: Differences in outcome and toxicity between Asian and caucasian patients with lung cancer treated with systemic therapy
Authors: Soo, R.A. 
Kawaguchi, T.
Loh, M. 
Ou, S.-H.I.
Shieh, M.P.
Cho, B.-C.
Mok, T.S.
Soong, R. 
Keywords: Asian
caucasian
chemotherapy
ethnicity
lung cancer
NSCLC
targeted therapy
Issue Date: Apr-2012
Citation: Soo, R.A., Kawaguchi, T., Loh, M., Ou, S.-H.I., Shieh, M.P., Cho, B.-C., Mok, T.S., Soong, R. (2012-04). Differences in outcome and toxicity between Asian and caucasian patients with lung cancer treated with systemic therapy. Future Oncology 8 (4) : 451-462. ScholarBank@NUS Repository. https://doi.org/10.2217/fon.12.25
Abstract: It is increasingly recognized that differences in overall survival and toxicity exist between Asian and caucasian patients with small-cell and non-small-cell lung cancer, with a longer survival, higher response rates and greater toxicity to chemotherapy and targeted therapy reported in Asian patients. Two global studies are used to illustrate how the proportions of Asian patients can influence survival outcome. Ethnicity is an important and complex characteristic that should considered in the design and conduct of a global clinical study, as the safety, tolerability and response may vary between Asian and caucasian patients. Whether ethnic differences in lung cancer survival are attributed to genetic differences among races or are simply a surrogate marker of differences in access to healthcare because of socioeconomic differences is unclear. Carefully designed prospective studies investigating ethnic-specific determinants of sensitivity and toxicity to systemic therapy are warranted. © 2012 Future Medicine Ltd.
Source Title: Future Oncology
URI: http://scholarbank.nus.edu.sg/handle/10635/110812
ISSN: 14796694
DOI: 10.2217/fon.12.25
Appears in Collections:Staff Publications

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