Please use this identifier to cite or link to this item:
|Title:||Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme||Authors:||Lee, R.T.H.
|Issue Date:||15-Dec-2013||Citation:||Lee, R.T.H., Nagai, H., Nakaya, Y., Sheng, G., Trainor, P.A., Weston, J.A., Thiery, J.P. (2013-12-15). Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme. Development (Cambridge) 140 (24) : 4890-4902. ScholarBank@NUS Repository. https://doi.org/10.1242/dev.094680||Abstract:||The neural crest is a transient structure unique to vertebrate embryos that gives rise to multiple lineages along the rostrocaudal axis. In cranial regions, neural crest cells are thought to differentiate into chondrocytes, osteocytes, pericytes and stromal cells, which are collectively termed ectomesenchyme derivatives, as well as pigment and neuronal derivatives. There is still no consensus as to whether the neural crest can be classified as a homogenous multipotent population of cells. This unresolved controversy has important implications for the formation of ectomesenchyme and for confirmation of whether the neural fold is compartmentalized into distinct domains, each with a different repertoire of derivatives. Here we report in mouse and chicken that cells in the neural fold delaminate over an extended period from different regions of the cranial neural fold to give rise to cells with distinct fates. Importantly, cells that give rise to ectomesenchyme undergo epithelial-mesenchymal transition from a lateral neural fold domain that does not express definitive neural markers, such as Sox1 and N-cadherin. Additionally, the inference that cells originating from the cranial neural ectoderm have a common origin and cell fate with trunk neural crest cells prompted us to revisit the issue of what defines the neural crest and the origin of the ectomesenchyme. © 2013. Published by The Company of Biologists Ltd.||Source Title:||Development (Cambridge)||URI:||http://scholarbank.nus.edu.sg/handle/10635/110727||ISSN:||09501991||DOI:||10.1242/dev.094680|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 18, 2019
WEB OF SCIENCETM
checked on Jun 10, 2019
checked on May 25, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.