Please use this identifier to cite or link to this item:
Title: LRRK2 variant associated with Alzheimer's disease
Authors: Zhao, Y.
Ho, P.
Yih, Y.
Chen, C.
Lee, W.L.
Tan, E.K. 
Keywords: Alzheimer's disease
Issue Date: Nov-2011
Citation: Zhao, Y., Ho, P., Yih, Y., Chen, C., Lee, W.L., Tan, E.K. (2011-11). LRRK2 variant associated with Alzheimer's disease. Neurobiology of Aging 32 (11) : 1990-1993. ScholarBank@NUS Repository.
Abstract: Overlapping neurodegenerative pathologies (including Alzheimer's disease, AD) have been described in Parkinson's disease (PD) patients with leucine-rich repeat kinase-2 (LRRK2) mutations. We analyzed a LRRK2 PD (R1628P) risk variant in a group of 885 subjects comprising of AD and controls. The frequency of the R1628P allele was higher in AD compared to controls (3.5% vs. 1.6%, OR 2.3, 95 CI 1.2-4.4, p=0.018). In vitro, the mean percentage of apoptosis and cell death observed for the R1628P transfected human cell lines was higher compared to wild type 21.8 ± 1.9, vs. 17.1 ± 1.3, p
Source Title: Neurobiology of Aging
ISSN: 01974580
DOI: 10.1016/j.neurobiolaging.2009.11.019
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.