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|Title:||LRRK2 variant associated with Alzheimer's disease||Authors:||Zhao, Y.
|Issue Date:||Nov-2011||Citation:||Zhao, Y., Ho, P., Yih, Y., Chen, C., Lee, W.L., Tan, E.K. (2011-11). LRRK2 variant associated with Alzheimer's disease. Neurobiology of Aging 32 (11) : 1990-1993. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2009.11.019||Abstract:||Overlapping neurodegenerative pathologies (including Alzheimer's disease, AD) have been described in Parkinson's disease (PD) patients with leucine-rich repeat kinase-2 (LRRK2) mutations. We analyzed a LRRK2 PD (R1628P) risk variant in a group of 885 subjects comprising of AD and controls. The frequency of the R1628P allele was higher in AD compared to controls (3.5% vs. 1.6%, OR 2.3, 95 CI 1.2-4.4, p=0.018). In vitro, the mean percentage of apoptosis and cell death observed for the R1628P transfected human cell lines was higher compared to wild type 21.8 ± 1.9, vs. 17.1 ± 1.3, p||Source Title:||Neurobiology of Aging||URI:||http://scholarbank.nus.edu.sg/handle/10635/110163||ISSN:||01974580||DOI:||10.1016/j.neurobiolaging.2009.11.019|
|Appears in Collections:||Staff Publications|
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