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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neurobiolaging.2009.11.019
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dc.titleLRRK2 variant associated with Alzheimer's disease
dc.contributor.authorZhao, Y.
dc.contributor.authorHo, P.
dc.contributor.authorYih, Y.
dc.contributor.authorChen, C.
dc.contributor.authorLee, W.L.
dc.contributor.authorTan, E.K.
dc.date.accessioned2014-11-26T08:29:16Z
dc.date.available2014-11-26T08:29:16Z
dc.date.issued2011-11
dc.identifier.citationZhao, Y., Ho, P., Yih, Y., Chen, C., Lee, W.L., Tan, E.K. (2011-11). LRRK2 variant associated with Alzheimer's disease. Neurobiology of Aging 32 (11) : 1990-1993. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2009.11.019
dc.identifier.issn01974580
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110163
dc.description.abstractOverlapping neurodegenerative pathologies (including Alzheimer's disease, AD) have been described in Parkinson's disease (PD) patients with leucine-rich repeat kinase-2 (LRRK2) mutations. We analyzed a LRRK2 PD (R1628P) risk variant in a group of 885 subjects comprising of AD and controls. The frequency of the R1628P allele was higher in AD compared to controls (3.5% vs. 1.6%, OR 2.3, 95 CI 1.2-4.4, p=0.018). In vitro, the mean percentage of apoptosis and cell death observed for the R1628P transfected human cell lines was higher compared to wild type 21.8 ± 1.9, vs. 17.1 ± 1.3, p
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neurobiolaging.2009.11.019
dc.sourceScopus
dc.subjectAlzheimer's disease
dc.subjectLRRK2
dc.subjectVariants
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1016/j.neurobiolaging.2009.11.019
dc.description.sourcetitleNeurobiology of Aging
dc.description.volume32
dc.description.issue11
dc.description.page1990-1993
dc.description.codenNEAGD
dc.identifier.isiut000295220700007
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