LRRK2 R1628P increases risk of Parkinson's disease: Replication evidence

Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00439-008-0544-2

Title:	LRRK2 R1628P increases risk of Parkinson's disease: Replication evidence
Authors:	Tan, E.K. Tan, L.C. Lim, H.Q. Li, R. Tang, M. Yih, Y. Pavanni, R. Prakash, K.M. Fook-Chong, S. Zhao, Y.
Issue Date:	2008
Citation:	Tan, E.K., Tan, L.C., Lim, H.Q., Li, R., Tang, M., Yih, Y., Pavanni, R., Prakash, K.M., Fook-Chong, S., Zhao, Y. (2008). LRRK2 R1628P increases risk of Parkinson's disease: Replication evidence. Human Genetics 124 (3) : 287-288. ScholarBank@NUS Repository. https://doi.org/10.1007/s00439-008-0544-2
Abstract:	We showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson's disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1-5.6). In the multivariate logistic regression (with adjustments made for the effect of age, age of onset, and gender), the heterozygous R1628P genotype was associated with an increased risk of PD compared to controls (OR 3.3, 95% CI 1.4- 7.9, P = 0.007). We provided an independent confirmation that the R1628P variant increases the risk of PD among Chinese. © Springer-Verlag 2008.
Source Title:	Human Genetics
URI:	http://scholarbank.nus.edu.sg/handle/10635/110162
ISSN:	03406717
DOI:	10.1007/s00439-008-0544-2
Appears in Collections:	Staff Publications

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