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Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00439-008-0544-2
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dc.titleLRRK2 R1628P increases risk of Parkinson's disease: Replication evidence
dc.contributor.authorTan, E.K.
dc.contributor.authorTan, L.C.
dc.contributor.authorLim, H.Q.
dc.contributor.authorLi, R.
dc.contributor.authorTang, M.
dc.contributor.authorYih, Y.
dc.contributor.authorPavanni, R.
dc.contributor.authorPrakash, K.M.
dc.contributor.authorFook-Chong, S.
dc.contributor.authorZhao, Y.
dc.date.accessioned2014-11-26T08:29:16Z
dc.date.available2014-11-26T08:29:16Z
dc.date.issued2008
dc.identifier.citationTan, E.K., Tan, L.C., Lim, H.Q., Li, R., Tang, M., Yih, Y., Pavanni, R., Prakash, K.M., Fook-Chong, S., Zhao, Y. (2008). LRRK2 R1628P increases risk of Parkinson's disease: Replication evidence. Human Genetics 124 (3) : 287-288. ScholarBank@NUS Repository. https://doi.org/10.1007/s00439-008-0544-2
dc.identifier.issn03406717
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110162
dc.description.abstractWe showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson's disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1-5.6). In the multivariate logistic regression (with adjustments made for the effect of age, age of onset, and gender), the heterozygous R1628P genotype was associated with an increased risk of PD compared to controls (OR 3.3, 95% CI 1.4- 7.9, P = 0.007). We provided an independent confirmation that the R1628P variant increases the risk of PD among Chinese. © Springer-Verlag 2008.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s00439-008-0544-2
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1007/s00439-008-0544-2
dc.description.sourcetitleHuman Genetics
dc.description.volume124
dc.description.issue3
dc.description.page287-288
dc.description.codenHUGED
dc.identifier.isiut000259909500011
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