Please use this identifier to cite or link to this item:
Title: Estimation of intervention effects using recurrent event time data in the presence of event dependence and a cured fraction
Authors: Xu, Y. 
Lam, K.F.
Cheung, Y.B. 
Keywords: Event dependence
Frailty mixture model
Intervention effects
Recurrent events
Issue Date: 15-Jun-2014
Citation: Xu, Y., Lam, K.F., Cheung, Y.B. (2014-06-15). Estimation of intervention effects using recurrent event time data in the presence of event dependence and a cured fraction. Statistics in Medicine 33 (13) : 2263-2274. ScholarBank@NUS Repository.
Abstract: Recurrent event data with a fraction of subjects having zero event are often seen in randomized clinical trials. Those with zero event may belong to a cured (or non-susceptible) fraction. Event dependence refers to the situation that a person's past event history affects his future event occurrences. In the presence of event dependence, an intervention may have an impact on the event rate in the non-cured through two pathways-a primary effect directly on the outcome event and a secondary effect mediated through event dependence. The primary effect combined with the secondary effect is the total effect. We propose a frailty mixture model and a two-step estimation procedure for the estimation of the effect of an intervention on the probability of cure and the total effect on event rate in the non-cured. A summary measure of intervention effects is derived. The performance of the proposed model is evaluated by simulation. Data on respiratory exacerbations from a randomized, placebo-controlled trial are re-analyzed for illustration. © 2014 John Wiley & Sons, Ltd.
Source Title: Statistics in Medicine
ISSN: 10970258
DOI: 10.1002/sim.6093
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Dec 1, 2021


checked on Nov 24, 2021

Page view(s)

checked on Dec 2, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.