Please use this identifier to cite or link to this item: https://doi.org/10.1002/sim.6093
Title: Estimation of intervention effects using recurrent event time data in the presence of event dependence and a cured fraction
Authors: Xu, Y. 
Lam, K.F.
Cheung, Y.B. 
Keywords: Event dependence
Frailty mixture model
Intervention effects
Recurrent events
Issue Date: 15-Jun-2014
Citation: Xu, Y., Lam, K.F., Cheung, Y.B. (2014-06-15). Estimation of intervention effects using recurrent event time data in the presence of event dependence and a cured fraction. Statistics in Medicine 33 (13) : 2263-2274. ScholarBank@NUS Repository. https://doi.org/10.1002/sim.6093
Abstract: Recurrent event data with a fraction of subjects having zero event are often seen in randomized clinical trials. Those with zero event may belong to a cured (or non-susceptible) fraction. Event dependence refers to the situation that a person's past event history affects his future event occurrences. In the presence of event dependence, an intervention may have an impact on the event rate in the non-cured through two pathways-a primary effect directly on the outcome event and a secondary effect mediated through event dependence. The primary effect combined with the secondary effect is the total effect. We propose a frailty mixture model and a two-step estimation procedure for the estimation of the effect of an intervention on the probability of cure and the total effect on event rate in the non-cured. A summary measure of intervention effects is derived. The performance of the proposed model is evaluated by simulation. Data on respiratory exacerbations from a randomized, placebo-controlled trial are re-analyzed for illustration. © 2014 John Wiley & Sons, Ltd.
Source Title: Statistics in Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/110065
ISSN: 10970258
DOI: 10.1002/sim.6093
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