Please use this identifier to cite or link to this item:
Title: Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology
Authors: Teh, C.A.
Lee, T.-S.
Kuchibhatla, M.
Ashley-Koch, A.
MacFall, J.
Krishnan, R. 
Beyer, J.
Issue Date: 30-Jul-2012
Citation: Teh, C.A., Lee, T.-S., Kuchibhatla, M., Ashley-Koch, A., MacFall, J., Krishnan, R., Beyer, J. (2012-07-30). Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology. PLoS ONE 7 (7) : -. ScholarBank@NUS Repository.
Abstract: In this study of the effect of bipolar status and presence of BDNF Val66Met polymorphism on differences in regional brain volumes, we hypothesized based on previous studies that 1) bipolar subjects will have smaller regional brain volumes than healthy controls; 2) BDNF Met66 allele carriers within the same population are likely to have smaller regional brain volumes as compared to Val66 homozygyotes. In our Caucasian sample of 166 bipolar subjects and 64 gender-matched healthy controls, we found significant decreases in total (p = 0.005) and regional gray matter volumes in bipolar patients compared to healthy controls, more pronounced in the inferior and posterior parts of the brain, together with a concomitant increase in total CSF (p = 0.012) particularly in the lateral ventricles (p = 0.023). However, there was no difference in white matter volumes noted by other studies. Furthermore we did not find significant differences in other brain regions that have been reported by other authors. Nor did we find a significant effect of BDNF on these measurements. © 2012 Teh et al.
Source Title: PLoS ONE
ISSN: 19326203
DOI: 10.1371/journal.pone.0038469
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2012-bipolar_disorder_brain-derived_neurotrophic_factor-pub.pdf87.22 kBAdobe PDF



Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.