Please use this identifier to cite or link to this item:
|Title:||A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2||Authors:||Wu, Y.
Van Dam, R.M.
|Issue Date:||Feb-2014||Citation:||Wu, Y., Gao, H., Li, H., Tabara, Y., Nakatochi, M., Chiu, Y.-F., Park, E.J., Wen, W., Adair, L.S., Borja, J.B., Cai, Q., Chang, Y.-C., Chen, P., Croteau-Chonka, D.C., Fogarty, M.P., Gan, W., He, C.-T., Hsiung, C.A., Hwu, C.-M., Ichihara, S., Igase, M., Jo, J., Kato, N., Kawamoto, R., Kuzawa, C.W., Lee, J.J.M., Liu, J., Lu, L., Mcdade, T.W., Osawa, H., Sheu, W.H.-H., Teo, Y., Vadlamudi, S., Van Dam, R.M., Wang, Y., Xiang, Y.-B., Yamamoto, K., Ye, X., Young, T.L., Zheng, W., Zhu, J., Shu, X.-O., Shin, C., Jee, S.H., Chuang, L.-M., Miki, T., Yokota, M., Lin, X., Mohlke, K.L., Tai, E.S. (2014-02). A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. Human Molecular Genetics 23 (4) : 1108-1119. ScholarBank@NUS Repository. https://doi.org/10.1093/hmg/ddt488||Abstract:||Blood levels of adiponectin, an adipocyte-secreted protein correlated with metabolic and cardiovascular risks, are highly heritable. Genome-wide association (GWA) studies for adiponectin levels have identified 14 loci harboring variants associated with blood levels of adiponectin. To identify novel adiponectin-associated loci, particularly those of importance in East Asians, we conducted a meta-analysis of GWA studies for adiponectin in 7827 individuals, followed by two stages of replications in 4298 and 5954 additional individuals. We identified a novel adiponectin-associated locus on chromosome 10 near WDR11-FGFR2 (P = 3.0 × 10-14) and provided suggestive evidence for a locus on chromosome 12 near OR8S1-LALBA (P = 1.2 × 10-7). Of the adiponectinassociated loci previously described, we confirmed the association at CDH13 (P = 6.8 × 10-165), ADIPOQ (P = 1.8 × 10-22), PEPD (P = 3.6 × 10-12), CMIP (P = 2.1 × 10-10), ZNF664 (P = 2.3 × 10-7) and GPR109A (P = 7.4 × 10-6). Conditional analysis at ADIPOQ revealed a second signal with suggestive evidence of association only after conditioning on the lead SNP (Pinitial = 0.020; Pconditional = 7.0 × 10-7). We further confirmed the independence of two pairs of closely located loci (||Source Title:||Human Molecular Genetics||URI:||http://scholarbank.nus.edu.sg/handle/10635/109892||ISSN:||09646906||DOI:||10.1093/hmg/ddt488|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 28, 2020
WEB OF SCIENCETM
checked on Oct 19, 2020
checked on Oct 23, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.