Please use this identifier to cite or link to this item:
|Title:||A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2|
Van Dam, R.M.
|Citation:||Wu, Y., Gao, H., Li, H., Tabara, Y., Nakatochi, M., Chiu, Y.-F., Park, E.J., Wen, W., Adair, L.S., Borja, J.B., Cai, Q., Chang, Y.-C., Chen, P., Croteau-Chonka, D.C., Fogarty, M.P., Gan, W., He, C.-T., Hsiung, C.A., Hwu, C.-M., Ichihara, S., Igase, M., Jo, J., Kato, N., Kawamoto, R., Kuzawa, C.W., Lee, J.J.M., Liu, J., Lu, L., Mcdade, T.W., Osawa, H., Sheu, W.H.-H., Teo, Y., Vadlamudi, S., Van Dam, R.M., Wang, Y., Xiang, Y.-B., Yamamoto, K., Ye, X., Young, T.L., Zheng, W., Zhu, J., Shu, X.-O., Shin, C., Jee, S.H., Chuang, L.-M., Miki, T., Yokota, M., Lin, X., Mohlke, K.L., Tai, E.S. (2014-02). A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. Human Molecular Genetics 23 (4) : 1108-1119. ScholarBank@NUS Repository. https://doi.org/10.1093/hmg/ddt488|
|Abstract:||Blood levels of adiponectin, an adipocyte-secreted protein correlated with metabolic and cardiovascular risks, are highly heritable. Genome-wide association (GWA) studies for adiponectin levels have identified 14 loci harboring variants associated with blood levels of adiponectin. To identify novel adiponectin-associated loci, particularly those of importance in East Asians, we conducted a meta-analysis of GWA studies for adiponectin in 7827 individuals, followed by two stages of replications in 4298 and 5954 additional individuals. We identified a novel adiponectin-associated locus on chromosome 10 near WDR11-FGFR2 (P = 3.0 × 10-14) and provided suggestive evidence for a locus on chromosome 12 near OR8S1-LALBA (P = 1.2 × 10-7). Of the adiponectinassociated loci previously described, we confirmed the association at CDH13 (P = 6.8 × 10-165), ADIPOQ (P = 1.8 × 10-22), PEPD (P = 3.6 × 10-12), CMIP (P = 2.1 × 10-10), ZNF664 (P = 2.3 × 10-7) and GPR109A (P = 7.4 × 10-6). Conditional analysis at ADIPOQ revealed a second signal with suggestive evidence of association only after conditioning on the lead SNP (Pinitial = 0.020; Pconditional = 7.0 × 10-7). We further confirmed the independence of two pairs of closely located loci (|
|Source Title:||Human Molecular Genetics|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 20, 2018
WEB OF SCIENCETM
checked on Sep 10, 2018
checked on Sep 21, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.