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Title: A practical guide for multivariate analysis of dichotomous outcomes
Authors: Lee, J.
Chuen, S.T. 
Kee, S.C. 
Keywords: Alternatives to logistic regression
Cross-sectional studies
Risk ratio vs odds ratio
Issue Date: Aug-2009
Citation: Lee, J.,Chuen, S.T.,Kee, S.C. (2009-08). A practical guide for multivariate analysis of dichotomous outcomes. Annals of the Academy of Medicine Singapore 38 (8) : 714-719. ScholarBank@NUS Repository.
Abstract: A dichotomous (2-category) outcome variable is often encountered in biomedical research, and Multiple Logistic Regression is often deployed for the analysis of such data. As Logistic Regression estimates the Odds Ratio (OR) as an effect measure, it is only suitable for case-control studies. For cross-sectional and time-to-event studies, the Prevalence Ratio and Cumulative Incidence Ratio can be estimated and easily interpreted. The logistic regression will produce the OR which is difficult to interpret in these studies. In this report, we reviewed 3 alternative multivariate statistical models to replace Logistic Regression for the analysis of data from cross-sectional and time-to-event studies, viz, Modified Cox Proportional Hazard Regression Model, Log-Binomial Regression Model and Poisson Regression Model incorporating the Robust Sandwich Variance. Although none of the models is without flaws, we conclude the last model is the most viable. A numeric example is given to compare the statistical results obtained from all 4 models.
Source Title: Annals of the Academy of Medicine Singapore
ISSN: 03044602
Appears in Collections:Staff Publications

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