Please use this identifier to cite or link to this item: https://doi.org/10.4049/jimmunol.0902663
Title: Suppression of host innate immune response by Burkholderia pseudomallei through the virulence factor TssM
Authors: Tan, K.S. 
Chen, Y.
Lim, Y.-C.
Tan, G.-Y.G.
Liu, Y.
Lim, Y.-T.
MacAry, P.
Gan, Y.-H. 
Issue Date: 1-May-2010
Citation: Tan, K.S., Chen, Y., Lim, Y.-C., Tan, G.-Y.G., Liu, Y., Lim, Y.-T., MacAry, P., Gan, Y.-H. (2010-05-01). Suppression of host innate immune response by Burkholderia pseudomallei through the virulence factor TssM. Journal of Immunology 184 (9) : 5160-5171. ScholarBank@NUS Repository. https://doi.org/10.4049/jimmunol.0902663
Abstract: Burkholderia pseudomallei is a Gram-negative saprophyte that is the causative agent of melioidosis, a severe infectious disease endemic in Northern Australia and Southeast Asia. This organism has sparked much scientific interest in the West because of its classification as a potential bioterrorism agent by the U.S. Centers for Disease Control and Prevention. However, relatively little is known about its pathogenesis. We demonstrate that B. pseudomallei actively inhibits NF-κB and type I IFN pathway activation, thereby downregulating host inflammatory responses. We found the virulence factor TssM to be responsible for this activity. TssM interferes with the ubiquitination of critical signaling intermediates, including TNFR-associated factor-3, TNFR-associated factor-6, and IκBα. The expression but not secretion of TssM is regulated by the type III secretion system. We demonstrate that TssM is important for B. pseudomallei infection in vivo as inflammation in the tssM mutant-infected mice is more severe and corresponds to a more rapid death compared with wild-type bacteria-infected mice. Abs to TssM can be detected in the sera of melioidosis patients, indicating that TssM is functionally expressed in vivo and thus could contribute to bacterial pathogenesis in human melioidosis. Copyright © 2010 by The American Association of Immunologists, Inc.
Source Title: Journal of Immunology
URI: http://scholarbank.nus.edu.sg/handle/10635/109675
ISSN: 00221767
DOI: 10.4049/jimmunol.0902663
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

52
checked on Sep 11, 2020

WEB OF SCIENCETM
Citations

50
checked on Sep 11, 2020

Page view(s)

74
checked on Sep 19, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.