Please use this identifier to cite or link to this item:
|Title:||Prevalence and predictors of premature discontinuation of dual antiplatelet therapy after drug-eluting stent implantation: Importance of social factors in Asian patients||Authors:||Poh, C.-L.
Drug eluting stents
Stent thrombosis and compliance
|Issue Date:||Aug-2011||Citation:||Poh, C.-L., Chan, M.Y., Lau, C., Teo, S.-G., Low, A.F., Tan, H.-C., Lee, C.-H. (2011-08). Prevalence and predictors of premature discontinuation of dual antiplatelet therapy after drug-eluting stent implantation: Importance of social factors in Asian patients. Internal Medicine Journal 41 (8) : 623-629. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1445-5994.2009.02104.x||Abstract:||Aim: Premature discontinuation of antiplatelet therapy is an independent predictor of late stent thrombosis. We sought to determine the prevalence and predictors of premature discontinuation of antiplatelet therapy after drug-eluting stent implantation among patients in Asia. Methods: A total of 207 consecutive patients who underwent drug-eluting stent implantation at our institution was followed up after 1year. Premature discontinuation of antiplatelet therapy was defined as omission of aspirin and/or clopidogrel for 1week or more. Results: Four (1.9%) patients died and the remaining 203 patients formed the study population. Prevalence of premature discontinuation of antiplatelet therapy was 12.8% (n= 26, aspirin, n= 12; clopidogrel, n= 9; both, n= 5). The median duration between stent implantation and discontinuation of antiplatelet therapy was 2.8months. Reasons for discontinuation included cost (n= 1), gastric discomfort (n= 1), allergy (n= 3), bleeding (n= 3), advice from doctors (n= 7) and no reason (n= 11). Logistic regression showed that living alone was the only independent predictor of premature discontinuation of dual antiplatelet therapy (50.0% vs 11.3%, P= 0.001). Conclusion: Among Asian patients who have undergone drug-eluting stent implantation, 12.8% discontinued dual antiplatelet therapy within 12months. Living alone is associated with a fivefold increase in risk of premature drug discontinuation. © 2011 The Authors. Internal Medicine Journal © 2011 Royal Australasian College of Physicians.||Source Title:||Internal Medicine Journal||URI:||http://scholarbank.nus.edu.sg/handle/10635/109539||ISSN:||14440903||DOI:||10.1111/j.1445-5994.2009.02104.x|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 21, 2022
WEB OF SCIENCETM
checked on Nov 14, 2022
checked on Nov 24, 2022
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.