Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1445-5994.2009.02104.x
Title: Prevalence and predictors of premature discontinuation of dual antiplatelet therapy after drug-eluting stent implantation: Importance of social factors in Asian patients
Authors: Poh, C.-L.
Chan, M.Y.
Lau, C. 
Teo, S.-G. 
Low, A.F.
Tan, H.-C.
Lee, C.-H.
Keywords: Antiplatelet therapy
Drug eluting stents
Stent thrombosis and compliance
Issue Date: Aug-2011
Citation: Poh, C.-L., Chan, M.Y., Lau, C., Teo, S.-G., Low, A.F., Tan, H.-C., Lee, C.-H. (2011-08). Prevalence and predictors of premature discontinuation of dual antiplatelet therapy after drug-eluting stent implantation: Importance of social factors in Asian patients. Internal Medicine Journal 41 (8) : 623-629. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1445-5994.2009.02104.x
Abstract: Aim: Premature discontinuation of antiplatelet therapy is an independent predictor of late stent thrombosis. We sought to determine the prevalence and predictors of premature discontinuation of antiplatelet therapy after drug-eluting stent implantation among patients in Asia. Methods: A total of 207 consecutive patients who underwent drug-eluting stent implantation at our institution was followed up after 1year. Premature discontinuation of antiplatelet therapy was defined as omission of aspirin and/or clopidogrel for 1week or more. Results: Four (1.9%) patients died and the remaining 203 patients formed the study population. Prevalence of premature discontinuation of antiplatelet therapy was 12.8% (n= 26, aspirin, n= 12; clopidogrel, n= 9; both, n= 5). The median duration between stent implantation and discontinuation of antiplatelet therapy was 2.8months. Reasons for discontinuation included cost (n= 1), gastric discomfort (n= 1), allergy (n= 3), bleeding (n= 3), advice from doctors (n= 7) and no reason (n= 11). Logistic regression showed that living alone was the only independent predictor of premature discontinuation of dual antiplatelet therapy (50.0% vs 11.3%, P= 0.001). Conclusion: Among Asian patients who have undergone drug-eluting stent implantation, 12.8% discontinued dual antiplatelet therapy within 12months. Living alone is associated with a fivefold increase in risk of premature drug discontinuation. © 2011 The Authors. Internal Medicine Journal © 2011 Royal Australasian College of Physicians.
Source Title: Internal Medicine Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/109539
ISSN: 14440903
DOI: 10.1111/j.1445-5994.2009.02104.x
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