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Title: Glycemic index, retinal vascular caliber, and stroke mortality
Authors: Kaushik, S.
Wang, J.J.
Wong, T.Y. 
Flood, V.
Barclay, A.
Brand-Miller, J.
Mitchell, P.
Keywords: Carbohydrate
Glycemic index
Retinal vessels
Issue Date: 1-Jan-2009
Citation: Kaushik, S., Wang, J.J., Wong, T.Y., Flood, V., Barclay, A., Brand-Miller, J., Mitchell, P. (2009-01-01). Glycemic index, retinal vascular caliber, and stroke mortality. Stroke 40 (1) : 206-212. ScholarBank@NUS Repository.
Abstract: BACKGROUND AND PURPOSE: It is unclear whether diets with high glycemic index (GI) and low cereal fiber (CF) are associated with greater risk of stroke. We aimed to assess the relationship between dietary GI and CF content, retinal microvasculature changes, and stroke-related mortality. METHODS: The study consisted of a population-based cohort, 49+ years, examined at baseline (1992 to 1994). At baseline, participants completed validated food frequency questionnaires. Mean GI was calculated using an Australian database. Retinal arteriolar and venular diameters were measured from photographs. Mortality data were derived using the Australian National Death Index. RESULTS: Over 13 years, 95 of 2897 participants (3.5%) died from stroke. Increasing GI (hazard ratio, 1.91; 95% CI, 1.01 to 3.47, highest versus lowest tertile) and decreasing CF (hazard ratio, 2.13; 95% CI, 1.19 to 3.80, lowest versus highest tertile) predicted greater risk of stroke death adjusting for multiple stroke risk factors. Persons consuming food in the highest GI tertile and lowest CF tertile had a 5-fold increased risk of stroke death (hazard ratio, 5.06; 95% CI, 1.67 to 15.22). Increasing GI and decreasing CF were also associated with retinal venular caliber widening (Ptrend
Source Title: Stroke
ISSN: 00392499
DOI: 10.1161/STROKEAHA.108.513812
Appears in Collections:Staff Publications

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