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Title: Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes
Authors: Selvin, E.
Ning, Y.
Steffes, M.W.
Bash, L.D.
Klein, R.
Wong, T.Y. 
Astor, B.C.
Sharrett, A.R.
Brancati, F.L.
Coresh, J.
Issue Date: Jan-2011
Citation: Selvin, E., Ning, Y., Steffes, M.W., Bash, L.D., Klein, R., Wong, T.Y., Astor, B.C., Sharrett, A.R., Brancati, F.L., Coresh, J. (2011-01). Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetes. Diabetes 60 (1) : 298-305. ScholarBank@NUS Repository.
Abstract: OBJECTIVE: Glycated hemoglobin was recently recommended for use as a diagnostic test for diabetes. We examined the association between 2010 American Diabetes Association diagnostic cut points for glycated hemoglobin and microvascular outcomes (chronic kidney disease, end-stage renal disease [ESRD], and retinopathy) and formally tested for the presence of risk thresholds in the relationships of glycated hemoglobin with these outcomes. RESEARCH DESIGN AND METHODS: Prospective cohort and cross-sectional analyses of 11,357 participants (773 with a history of diagnosed diabetes) from the Atherosclerosis Risk in Communities (ARIC) Study. RESULTS: During a median of 14 years of follow-up of individuals without diagnosed diabetes at baseline, clinical categories of glycated hemoglobin were associated with risk of chronic kidney disease, with adjusted hazard ratios (HRs) of 1.12 (0.94 -1.34) and 1.39 (1.04 -1.85) for glycated hemoglobin 5.7- 6.4% and
Source Title: Diabetes
ISSN: 00121797
DOI: 10.2337/db10-1198
Appears in Collections:Staff Publications

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