Please use this identifier to cite or link to this item: https://doi.org/10.1038/ng.921
Title: Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
Authors: Kooner, J.S.
Saleheen, D.
Sim, X. 
Sehmi, J.
Zhang, W.
Frossard, P.
Been, L.F.
Chia, K.-S. 
Dimas, A.S.
Hassanali, N.
Jafar, T.
Jowett, J.B.M.
Li, X.
Radha, V.
Rees, S.D.
Takeuchi, F.
Young, R.
Aung, T.
Basit, A.
Chidambaram, M.
Das, D.
Grundberg, E.
Hedman, Å.K.
Hydrie, Z.I.
Islam, M.
Khor, C.-C. 
Kowlessur, S.
Kristensen, M.M.
Liju, S.
Lim, W.-Y. 
Matthews, D.R.
Liu, J.
Morris, A.P.
Nica, A.C.
Pinidiyapathirage, J.M.
Prokopenko, I.
Rasheed, A.
Samuel, M.
Shah, N.
Shera, A.S.
Small, K.S.
Suo, C. 
Wickremasinghe, A.R.
Wong, T.Y. 
Yang, M.
Zhang, F.
Abecasis, G.R.
Barnett, A.H.
Caulfield, M.
Deloukas, P.
Frayling, T.M.
Froguel, P.
Kato, N.
Katulanda, P.
Kelly, M.A.
Liang, J.
Mohan, V.
Sanghera, D.K.
Scott, J.
Seielstad, M.
Zimmet, P.Z.
Elliott, P.
Teo, Y.Y. 
McCarthy, M.I.
Danesh, J.
Tai, E.S.
Chambers, J.C.
Issue Date: Oct-2011
Citation: Kooner, J.S., Saleheen, D., Sim, X., Sehmi, J., Zhang, W., Frossard, P., Been, L.F., Chia, K.-S., Dimas, A.S., Hassanali, N., Jafar, T., Jowett, J.B.M., Li, X., Radha, V., Rees, S.D., Takeuchi, F., Young, R., Aung, T., Basit, A., Chidambaram, M., Das, D., Grundberg, E., Hedman, Å.K., Hydrie, Z.I., Islam, M., Khor, C.-C., Kowlessur, S., Kristensen, M.M., Liju, S., Lim, W.-Y., Matthews, D.R., Liu, J., Morris, A.P., Nica, A.C., Pinidiyapathirage, J.M., Prokopenko, I., Rasheed, A., Samuel, M., Shah, N., Shera, A.S., Small, K.S., Suo, C., Wickremasinghe, A.R., Wong, T.Y., Yang, M., Zhang, F., Abecasis, G.R., Barnett, A.H., Caulfield, M., Deloukas, P., Frayling, T.M., Froguel, P., Kato, N., Katulanda, P., Kelly, M.A., Liang, J., Mohan, V., Sanghera, D.K., Scott, J., Seielstad, M., Zimmet, P.Z., Elliott, P., Teo, Y.Y., McCarthy, M.I., Danesh, J., Tai, E.S., Chambers, J.C. (2011-10). Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nature Genetics 43 (10) : 984-989. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.921
Abstract: We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and 14,458 controls drawn from studies in London, Pakistan and Singapore. We identified 20 independent SNPs associated with T2D at P < 10 -4 for testing in a replication sample of 13,170 cases and 25,398 controls, also all of South Asian ancestry. In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 × 10 -8 to P = 1.9 × 10 -11). SNPs at GRB14 were also associated with insulin sensitivity (P = 5.0 × 10 -4), and SNPs at ST6GAL1 and HNF4A were also associated with pancreatic beta-cell function (P = 0.02 and P = 0.001, respectively). Our findings provide additional insight into mechanisms underlying T2D and show the potential for new discovery from genetic association studies in South Asians, a population with increased susceptibility to T2D. © 2011 Nature America, Inc. All rights reserved.
Source Title: Nature Genetics
URI: http://scholarbank.nus.edu.sg/handle/10635/109364
ISSN: 10614036
DOI: 10.1038/ng.921
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

328
checked on Jan 22, 2020

WEB OF SCIENCETM
Citations

314
checked on Jan 22, 2020

Page view(s)

108
checked on Jan 25, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.