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Title: Angiotensin-converting enzyme gene and retinal arteriolar narrowing: The Funagata Study
Authors: Tanabe, Y.
Kawasaki, R.
Wang, J.J.
Wong, T.Y. 
Mitchell, P.
Daimon, M.
Oizumi, T.
Kato, T.
Kawata, S.
Kayama, T.
Yamashita, H.
Issue Date: 2009
Citation: Tanabe, Y., Kawasaki, R., Wang, J.J., Wong, T.Y., Mitchell, P., Daimon, M., Oizumi, T., Kato, T., Kawata, S., Kayama, T., Yamashita, H. (2009). Angiotensin-converting enzyme gene and retinal arteriolar narrowing: The Funagata Study. Journal of Human Hypertension 23 (12) : 788-793. ScholarBank@NUS Repository.
Abstract: The purpose of this study is to determine whether the angiotensin-converting enzyme (ACE) gene polymorphism is associated with retinal arteriolar narrowing, a subclinical marker of chronic hypertension. The Funagata Study examined a population-based sample of Japanese aged 35 + years; 368 participants had both retinal vessel diameter measurements and ACE insertion/deletion (ACE I/D) polymorphism analyses performed. Assessment of retinal vessel diameter and retinal vessel wall signs followed the protocols used in the Blue Mountains Eye Study. ACE gene polymorphisms D/D, I/D and I/I were present in 34 (9.2%), 170 (46.2%) and 164 (44.5%) participants, respectively, distributed in Hardy-Weinberg equilibrium. After multivariable adjustment, retinal arteriolar diameter was significantly narrower in subjects with the D/D genotype compared to subjects with I/D and I/I genotypes (mean difference -6.49μm, 95% confidence interval (CI): -12.86μm, -0.11μm). Our study suggests that the ACE I/D polymorphism may be associated with subclinical structural arteriolar changes related to chronic hypertension.
Source Title: Journal of Human Hypertension
ISSN: 09509240
DOI: 10.1038/jhh.2009.27
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