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https://doi.org/10.1038/ng.2270
| Title: | Detectable clonal mosaicism and its relationship to aging and cancer | Authors: | Jacobs, K.B. Yeager, M. Zhou, W. Wacholder, S. Wang, Z. Rodriguez-Santiago, B. Hutchinson, A. Deng, X. Liu, C. Horner, M.-J. Cullen, M. Epstein, C.G. Burdett, L. Dean, M.C. Chatterjee, N. Sampson, J. Chung, C.C. Kovaks, J. Gapstur, S.M. Stevens, V.L. Teras, L.T. Gaudet, M.M. Albanes, D. Weinstein, S.J. Virtamo, J. Taylor, P.R. Freedman, N.D. Abnet, C.C. Goldstein, A.M. Hu, N. Yu, K. Yuan, J.-M. Liao, L. Ding, T. Qiao, Y.-L. Gao, Y.-T. Koh, W.-P. Xiang, Y.-B. Tang, Z.-Z. Fan, J.-H. Aldrich, M.C. Amos, C. Blot, W.J. Bock, C.H. Gillanders, E.M. Harris, C.C. Haiman, C.A. Henderson, B.E. Kolonel, L.N. Le Marchand, L. McNeill, L.H. Rybicki, B.A. Schwartz, A.G. Signorello, L.B. Spitz, M.R. Wiencke, J.K. Wrensch, M. Wu, X. Zanetti, K.A. Ziegler, R.G. Figueroa, J.D. Garcia-Closas, M. Malats, N. Marenne, G. Prokunina-Olsson, L. Baris, D. Schwenn, M. Johnson, A. Landi, M.T. Goldin, L. Consonni, D. Bertazzi, P.A. Rotunno, M. Rajaraman, P. Andersson, U. Freeman, L.E.B. Berg, C.D. Buring, J.E. Butler, M.A. Carreon, T. Feychting, M. Ahlbom, A. Gaziano, J.M. Giles, G.G. Hallmans, G. Hankinson, S.E. Hartge, P. Henriksson, R. Inskip, P.D. Johansen, C. Landgren, A. McKean-Cowdin, R. Michaud, D.S. Melin, B.S. Peters, U. Ruder, A.M. Sesso, H.D. Severi, G. Shu, X.-O. Visvanathan, K. White, E. Wolk, A. Zeleniuch-Jacquotte, A. Zheng, W. Silverman, D.T. Kogevinas, M. Gonzalez, J.R. Villa, O. Li, D. Duell, E.J. Risch, H.A. Olson, S.H. Kooperberg, C. Wolpin, B.M. Jiao, L. Hassan, M. Wheeler, W. Arslan, A.A. Bueno-De-Mesquita, H.B. Fuchs, C.S. Gallinger, S. Gross, M.D. Holly, E.A. Klein, A.P. Lacroix, A. Mandelson, M.T. Petersen, G. Boutron-Ruault, M.-C. Bracci, P.M. Canzian, F. Chang, K. Cotterchio, M. Giovannucci, E.L. Goggins, M. Bolton, J.A.H. Jenab, M. Khaw, K.-T. Krogh, V. Kurtz, R.C. McWilliams, R.R. Mendelsohn, J.B. Rabe, K.G. Riboli, E. Tjønneland, A. Tobias, G.S. Trichopoulos, D. Elena, J.W. Yu, H. Amundadottir, L. Stolzenberg-Solomon, R.Z. Kraft, P. Schumacher, F. Stram, D. Savage, S.A. Mirabello, L. Andrulis, I.L. Wunder, J.S. García, A.P. Sierrasesà maga, L. Barkauskas, D.A. Gorlick, R.G. Purdue, M. Chow, W.-H. Moore, L.E. Schwartz, K.L. Davis, F.G. Hsing, A.W. Berndt, S.I. Black, A. Wentzensen, N. Brinton, L.A. Lissowska, J. Peplonska, B. McGlynn, K.A. Cook, M.B. Graubard, B.I. Kratz, C.P. Greene, M.H. Erickson, R.L. Hunter, D.J. Thomas, G. Hoover, R.N. Real, F.X. Fraumeni Jr., J.F. Caporaso, N.E. Tucker, M. Rothman, N. Pérez-Jurado, L.A. Chanock, S.J. |
Issue Date: | Jun-2012 | Citation: | Jacobs, K.B., Yeager, M., Zhou, W., Wacholder, S., Wang, Z., Rodriguez-Santiago, B., Hutchinson, A., Deng, X., Liu, C., Horner, M.-J., Cullen, M., Epstein, C.G., Burdett, L., Dean, M.C., Chatterjee, N., Sampson, J., Chung, C.C., Kovaks, J., Gapstur, S.M., Stevens, V.L., Teras, L.T., Gaudet, M.M., Albanes, D., Weinstein, S.J., Virtamo, J., Taylor, P.R., Freedman, N.D., Abnet, C.C., Goldstein, A.M., Hu, N., Yu, K., Yuan, J.-M., Liao, L., Ding, T., Qiao, Y.-L., Gao, Y.-T., Koh, W.-P., Xiang, Y.-B., Tang, Z.-Z., Fan, J.-H., Aldrich, M.C., Amos, C., Blot, W.J., Bock, C.H., Gillanders, E.M., Harris, C.C., Haiman, C.A., Henderson, B.E., Kolonel, L.N., Le Marchand, L., McNeill, L.H., Rybicki, B.A., Schwartz, A.G., Signorello, L.B., Spitz, M.R., Wiencke, J.K., Wrensch, M., Wu, X., Zanetti, K.A., Ziegler, R.G., Figueroa, J.D., Garcia-Closas, M., Malats, N., Marenne, G., Prokunina-Olsson, L., Baris, D., Schwenn, M., Johnson, A., Landi, M.T., Goldin, L., Consonni, D., Bertazzi, P.A., Rotunno, M., Rajaraman, P., Andersson, U., Freeman, L.E.B., Berg, C.D., Buring, J.E., Butler, M.A., Carreon, T., Feychting, M., Ahlbom, A., Gaziano, J.M., Giles, G.G., Hallmans, G., Hankinson, S.E., Hartge, P., Henriksson, R., Inskip, P.D., Johansen, C., Landgren, A., McKean-Cowdin, R., Michaud, D.S., Melin, B.S., Peters, U., Ruder, A.M., Sesso, H.D., Severi, G., Shu, X.-O., Visvanathan, K., White, E., Wolk, A., Zeleniuch-Jacquotte, A., Zheng, W., Silverman, D.T., Kogevinas, M., Gonzalez, J.R., Villa, O., Li, D., Duell, E.J., Risch, H.A., Olson, S.H., Kooperberg, C., Wolpin, B.M., Jiao, L., Hassan, M., Wheeler, W., Arslan, A.A., Bueno-De-Mesquita, H.B., Fuchs, C.S., Gallinger, S., Gross, M.D., Holly, E.A., Klein, A.P., Lacroix, A., Mandelson, M.T., Petersen, G., Boutron-Ruault, M.-C., Bracci, P.M., Canzian, F., Chang, K., Cotterchio, M., Giovannucci, E.L., Goggins, M., Bolton, J.A.H., Jenab, M., Khaw, K.-T., Krogh, V., Kurtz, R.C., McWilliams, R.R., Mendelsohn, J.B., Rabe, K.G., Riboli, E., Tjønneland, A., Tobias, G.S., Trichopoulos, D., Elena, J.W., Yu, H., Amundadottir, L., Stolzenberg-Solomon, R.Z., Kraft, P., Schumacher, F., Stram, D., Savage, S.A., Mirabello, L., Andrulis, I.L., Wunder, J.S., García, A.P., Sierrasesà maga, L., Barkauskas, D.A., Gorlick, R.G., Purdue, M., Chow, W.-H., Moore, L.E., Schwartz, K.L., Davis, F.G., Hsing, A.W., Berndt, S.I., Black, A., Wentzensen, N., Brinton, L.A., Lissowska, J., Peplonska, B., McGlynn, K.A., Cook, M.B., Graubard, B.I., Kratz, C.P., Greene, M.H., Erickson, R.L., Hunter, D.J., Thomas, G., Hoover, R.N., Real, F.X., Fraumeni Jr., J.F., Caporaso, N.E., Tucker, M., Rothman, N., Pérez-Jurado, L.A., Chanock, S.J. (2012-06). Detectable clonal mosaicism and its relationship to aging and cancer. Nature Genetics 44 (6) : 651-658. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.2270 | Abstract: | In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10 -8). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10 -11). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases. © 2012 Nature America, Inc. All rights reserved. | Source Title: | Nature Genetics | URI: | http://scholarbank.nus.edu.sg/handle/10635/108905 | ISSN: | 10614036 | DOI: | 10.1038/ng.2270 |
| Appears in Collections: | Staff Publications |
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