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Please use this identifier to cite or link to this item: https://doi.org/10.1038/ng.2270
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dc.titleDetectable clonal mosaicism and its relationship to aging and cancer
dc.contributor.authorJacobs, K.B.
dc.contributor.authorYeager, M.
dc.contributor.authorZhou, W.
dc.contributor.authorWacholder, S.
dc.contributor.authorWang, Z.
dc.contributor.authorRodriguez-Santiago, B.
dc.contributor.authorHutchinson, A.
dc.contributor.authorDeng, X.
dc.contributor.authorLiu, C.
dc.contributor.authorHorner, M.-J.
dc.contributor.authorCullen, M.
dc.contributor.authorEpstein, C.G.
dc.contributor.authorBurdett, L.
dc.contributor.authorDean, M.C.
dc.contributor.authorChatterjee, N.
dc.contributor.authorSampson, J.
dc.contributor.authorChung, C.C.
dc.contributor.authorKovaks, J.
dc.contributor.authorGapstur, S.M.
dc.contributor.authorStevens, V.L.
dc.contributor.authorTeras, L.T.
dc.contributor.authorGaudet, M.M.
dc.contributor.authorAlbanes, D.
dc.contributor.authorWeinstein, S.J.
dc.contributor.authorVirtamo, J.
dc.contributor.authorTaylor, P.R.
dc.contributor.authorFreedman, N.D.
dc.contributor.authorAbnet, C.C.
dc.contributor.authorGoldstein, A.M.
dc.contributor.authorHu, N.
dc.contributor.authorYu, K.
dc.contributor.authorYuan, J.-M.
dc.contributor.authorLiao, L.
dc.contributor.authorDing, T.
dc.contributor.authorQiao, Y.-L.
dc.contributor.authorGao, Y.-T.
dc.contributor.authorKoh, W.-P.
dc.contributor.authorXiang, Y.-B.
dc.contributor.authorTang, Z.-Z.
dc.contributor.authorFan, J.-H.
dc.contributor.authorAldrich, M.C.
dc.contributor.authorAmos, C.
dc.contributor.authorBlot, W.J.
dc.contributor.authorBock, C.H.
dc.contributor.authorGillanders, E.M.
dc.contributor.authorHarris, C.C.
dc.contributor.authorHaiman, C.A.
dc.contributor.authorHenderson, B.E.
dc.contributor.authorKolonel, L.N.
dc.contributor.authorLe Marchand, L.
dc.contributor.authorMcNeill, L.H.
dc.contributor.authorRybicki, B.A.
dc.contributor.authorSchwartz, A.G.
dc.contributor.authorSignorello, L.B.
dc.contributor.authorSpitz, M.R.
dc.contributor.authorWiencke, J.K.
dc.contributor.authorWrensch, M.
dc.contributor.authorWu, X.
dc.contributor.authorZanetti, K.A.
dc.contributor.authorZiegler, R.G.
dc.contributor.authorFigueroa, J.D.
dc.contributor.authorGarcia-Closas, M.
dc.contributor.authorMalats, N.
dc.contributor.authorMarenne, G.
dc.contributor.authorProkunina-Olsson, L.
dc.contributor.authorBaris, D.
dc.contributor.authorSchwenn, M.
dc.contributor.authorJohnson, A.
dc.contributor.authorLandi, M.T.
dc.contributor.authorGoldin, L.
dc.contributor.authorConsonni, D.
dc.contributor.authorBertazzi, P.A.
dc.contributor.authorRotunno, M.
dc.contributor.authorRajaraman, P.
dc.contributor.authorAndersson, U.
dc.contributor.authorFreeman, L.E.B.
dc.contributor.authorBerg, C.D.
dc.contributor.authorBuring, J.E.
dc.contributor.authorButler, M.A.
dc.contributor.authorCarreon, T.
dc.contributor.authorFeychting, M.
dc.contributor.authorAhlbom, A.
dc.contributor.authorGaziano, J.M.
dc.contributor.authorGiles, G.G.
dc.contributor.authorHallmans, G.
dc.contributor.authorHankinson, S.E.
dc.contributor.authorHartge, P.
dc.contributor.authorHenriksson, R.
dc.contributor.authorInskip, P.D.
dc.contributor.authorJohansen, C.
dc.contributor.authorLandgren, A.
dc.contributor.authorMcKean-Cowdin, R.
dc.contributor.authorMichaud, D.S.
dc.contributor.authorMelin, B.S.
dc.contributor.authorPeters, U.
dc.contributor.authorRuder, A.M.
dc.contributor.authorSesso, H.D.
dc.contributor.authorSeveri, G.
dc.contributor.authorShu, X.-O.
dc.contributor.authorVisvanathan, K.
dc.contributor.authorWhite, E.
dc.contributor.authorWolk, A.
dc.contributor.authorZeleniuch-Jacquotte, A.
dc.contributor.authorZheng, W.
dc.contributor.authorSilverman, D.T.
dc.contributor.authorKogevinas, M.
dc.contributor.authorGonzalez, J.R.
dc.contributor.authorVilla, O.
dc.contributor.authorLi, D.
dc.contributor.authorDuell, E.J.
dc.contributor.authorRisch, H.A.
dc.contributor.authorOlson, S.H.
dc.contributor.authorKooperberg, C.
dc.contributor.authorWolpin, B.M.
dc.contributor.authorJiao, L.
dc.contributor.authorHassan, M.
dc.contributor.authorWheeler, W.
dc.contributor.authorArslan, A.A.
dc.contributor.authorBueno-De-Mesquita, H.B.
dc.contributor.authorFuchs, C.S.
dc.contributor.authorGallinger, S.
dc.contributor.authorGross, M.D.
dc.contributor.authorHolly, E.A.
dc.contributor.authorKlein, A.P.
dc.contributor.authorLacroix, A.
dc.contributor.authorMandelson, M.T.
dc.contributor.authorPetersen, G.
dc.contributor.authorBoutron-Ruault, M.-C.
dc.contributor.authorBracci, P.M.
dc.contributor.authorCanzian, F.
dc.contributor.authorChang, K.
dc.contributor.authorCotterchio, M.
dc.contributor.authorGiovannucci, E.L.
dc.contributor.authorGoggins, M.
dc.contributor.authorBolton, J.A.H.
dc.contributor.authorJenab, M.
dc.contributor.authorKhaw, K.-T.
dc.contributor.authorKrogh, V.
dc.contributor.authorKurtz, R.C.
dc.contributor.authorMcWilliams, R.R.
dc.contributor.authorMendelsohn, J.B.
dc.contributor.authorRabe, K.G.
dc.contributor.authorRiboli, E.
dc.contributor.authorTjønneland, A.
dc.contributor.authorTobias, G.S.
dc.contributor.authorTrichopoulos, D.
dc.contributor.authorElena, J.W.
dc.contributor.authorYu, H.
dc.contributor.authorAmundadottir, L.
dc.contributor.authorStolzenberg-Solomon, R.Z.
dc.contributor.authorKraft, P.
dc.contributor.authorSchumacher, F.
dc.contributor.authorStram, D.
dc.contributor.authorSavage, S.A.
dc.contributor.authorMirabello, L.
dc.contributor.authorAndrulis, I.L.
dc.contributor.authorWunder, J.S.
dc.contributor.authorGarcía, A.P.
dc.contributor.authorSierrasesà maga, L.
dc.contributor.authorBarkauskas, D.A.
dc.contributor.authorGorlick, R.G.
dc.contributor.authorPurdue, M.
dc.contributor.authorChow, W.-H.
dc.contributor.authorMoore, L.E.
dc.contributor.authorSchwartz, K.L.
dc.contributor.authorDavis, F.G.
dc.contributor.authorHsing, A.W.
dc.contributor.authorBerndt, S.I.
dc.contributor.authorBlack, A.
dc.contributor.authorWentzensen, N.
dc.contributor.authorBrinton, L.A.
dc.contributor.authorLissowska, J.
dc.contributor.authorPeplonska, B.
dc.contributor.authorMcGlynn, K.A.
dc.contributor.authorCook, M.B.
dc.contributor.authorGraubard, B.I.
dc.contributor.authorKratz, C.P.
dc.contributor.authorGreene, M.H.
dc.contributor.authorErickson, R.L.
dc.contributor.authorHunter, D.J.
dc.contributor.authorThomas, G.
dc.contributor.authorHoover, R.N.
dc.contributor.authorReal, F.X.
dc.contributor.authorFraumeni Jr., J.F.
dc.contributor.authorCaporaso, N.E.
dc.contributor.authorTucker, M.
dc.contributor.authorRothman, N.
dc.contributor.authorPérez-Jurado, L.A.
dc.contributor.authorChanock, S.J.
dc.date.accessioned2014-11-26T05:02:45Z
dc.date.available2014-11-26T05:02:45Z
dc.date.issued2012-06
dc.identifier.citationJacobs, K.B., Yeager, M., Zhou, W., Wacholder, S., Wang, Z., Rodriguez-Santiago, B., Hutchinson, A., Deng, X., Liu, C., Horner, M.-J., Cullen, M., Epstein, C.G., Burdett, L., Dean, M.C., Chatterjee, N., Sampson, J., Chung, C.C., Kovaks, J., Gapstur, S.M., Stevens, V.L., Teras, L.T., Gaudet, M.M., Albanes, D., Weinstein, S.J., Virtamo, J., Taylor, P.R., Freedman, N.D., Abnet, C.C., Goldstein, A.M., Hu, N., Yu, K., Yuan, J.-M., Liao, L., Ding, T., Qiao, Y.-L., Gao, Y.-T., Koh, W.-P., Xiang, Y.-B., Tang, Z.-Z., Fan, J.-H., Aldrich, M.C., Amos, C., Blot, W.J., Bock, C.H., Gillanders, E.M., Harris, C.C., Haiman, C.A., Henderson, B.E., Kolonel, L.N., Le Marchand, L., McNeill, L.H., Rybicki, B.A., Schwartz, A.G., Signorello, L.B., Spitz, M.R., Wiencke, J.K., Wrensch, M., Wu, X., Zanetti, K.A., Ziegler, R.G., Figueroa, J.D., Garcia-Closas, M., Malats, N., Marenne, G., Prokunina-Olsson, L., Baris, D., Schwenn, M., Johnson, A., Landi, M.T., Goldin, L., Consonni, D., Bertazzi, P.A., Rotunno, M., Rajaraman, P., Andersson, U., Freeman, L.E.B., Berg, C.D., Buring, J.E., Butler, M.A., Carreon, T., Feychting, M., Ahlbom, A., Gaziano, J.M., Giles, G.G., Hallmans, G., Hankinson, S.E., Hartge, P., Henriksson, R., Inskip, P.D., Johansen, C., Landgren, A., McKean-Cowdin, R., Michaud, D.S., Melin, B.S., Peters, U., Ruder, A.M., Sesso, H.D., Severi, G., Shu, X.-O., Visvanathan, K., White, E., Wolk, A., Zeleniuch-Jacquotte, A., Zheng, W., Silverman, D.T., Kogevinas, M., Gonzalez, J.R., Villa, O., Li, D., Duell, E.J., Risch, H.A., Olson, S.H., Kooperberg, C., Wolpin, B.M., Jiao, L., Hassan, M., Wheeler, W., Arslan, A.A., Bueno-De-Mesquita, H.B., Fuchs, C.S., Gallinger, S., Gross, M.D., Holly, E.A., Klein, A.P., Lacroix, A., Mandelson, M.T., Petersen, G., Boutron-Ruault, M.-C., Bracci, P.M., Canzian, F., Chang, K., Cotterchio, M., Giovannucci, E.L., Goggins, M., Bolton, J.A.H., Jenab, M., Khaw, K.-T., Krogh, V., Kurtz, R.C., McWilliams, R.R., Mendelsohn, J.B., Rabe, K.G., Riboli, E., Tjønneland, A., Tobias, G.S., Trichopoulos, D., Elena, J.W., Yu, H., Amundadottir, L., Stolzenberg-Solomon, R.Z., Kraft, P., Schumacher, F., Stram, D., Savage, S.A., Mirabello, L., Andrulis, I.L., Wunder, J.S., García, A.P., Sierrasesà maga, L., Barkauskas, D.A., Gorlick, R.G., Purdue, M., Chow, W.-H., Moore, L.E., Schwartz, K.L., Davis, F.G., Hsing, A.W., Berndt, S.I., Black, A., Wentzensen, N., Brinton, L.A., Lissowska, J., Peplonska, B., McGlynn, K.A., Cook, M.B., Graubard, B.I., Kratz, C.P., Greene, M.H., Erickson, R.L., Hunter, D.J., Thomas, G., Hoover, R.N., Real, F.X., Fraumeni Jr., J.F., Caporaso, N.E., Tucker, M., Rothman, N., Pérez-Jurado, L.A., Chanock, S.J. (2012-06). Detectable clonal mosaicism and its relationship to aging and cancer. Nature Genetics 44 (6) : 651-658. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.2270
dc.identifier.issn10614036
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108905
dc.description.abstractIn an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10 -8). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10 -11). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases. © 2012 Nature America, Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/ng.2270
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1038/ng.2270
dc.description.sourcetitleNature Genetics
dc.description.volume44
dc.description.issue6
dc.description.page651-658
dc.description.codenNGENE
dc.identifier.isiut000304551100011
Appears in Collections:Staff Publications

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