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Title: Smoking cessation and lung cancer risk in an Asian population: Findings from the Singapore Chinese health study
Authors: Wong, K.-Y.
Seow, A. 
Koh, W.-P. 
Shankar, A.
Lee, H.-P. 
Yu, M.C.
Keywords: cohort study
lung cancer
tobacco use
Issue Date: 28-Sep-2010
Citation: Wong, K.-Y., Seow, A., Koh, W.-P., Shankar, A., Lee, H.-P., Yu, M.C. (2010-09-28). Smoking cessation and lung cancer risk in an Asian population: Findings from the Singapore Chinese health study. British Journal of Cancer 103 (7) : 1093-1096. ScholarBank@NUS Repository.
Abstract: Background:Smoking cessation is an important strategy for reducing the harmful effects of tobacco, particularly in the prevention of lung cancer; however, prospective data on the impact of smoking cessation on lung cancer risk in Asian populations are limited.Methods:We studied a population-based cohort of Chinese men and women aged 45-74 years- participants of the Singapore Chinese Health Study. Information on smoking, lifestyle and dietary habits was collected at the time of recruitment in 1993-1998; and smoking status was assessed again at a second interview in 1999-2004 (mean interval 5.8 years). Participants were followed up to 31 December 2007, and incident cases of lung cancer were ascertained by linkage with population-wide registries.Results:Among 45 900 participants, there were 463 incident cases of lung cancer. Relative to current smokers, those who quit smoking subsequent to baseline assessment had a 28% decrease in the risk of lung cancer (adjusted hazard ratio (HR) 0.72; 95% CI (95% confidence interval): 0.53-0.98). The risk was less than half in ex-smokers who had quit before the first interview and maintained their status (HR 0.42; 95% CI: 0.32-0.56).Conclusions:Reduction in lung cancer incidence with smoking cessation in Asian populations is substantial and can be observed within a few years after quitting. © 2010 Cancer Research UK. All rights reserved.
Source Title: British Journal of Cancer
ISSN: 00070920
DOI: 10.1038/sj.bjc.6605782
Appears in Collections:Staff Publications

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