Please use this identifier to cite or link to this item:
|Title:||Retinal vascular caliber and diabetes in a multiethnic asian population||Authors:||Jeganathan, V.S.E.
|Keywords:||Diabetes mellitus impaired fasting glucose
Retinal vascular caliber
|Issue Date:||2009||Citation:||Jeganathan, V.S.E., Sabanayagam, C., Tai, E.S., Lee, J., Lamoureux, E., Sun, C., Kawasaki, R., Wong, T.Y. (2009). Retinal vascular caliber and diabetes in a multiethnic asian population. Microcirculation 16 (6) : 534-543. ScholarBank@NUS Repository. https://doi.org/10.1080/10739680902975222||Abstract:||Objective: The aim of this study was to examine the relationship of retinal vascular caliber with diabetes and impaired fasting glucose (IFG) in a multiethnic Asian population. Methods: This work was a population-based cross-sectional study comprising 3,404 Singaporean Chinese, Indian, and Malay participants. Retinal arteriolar and venular diameters, CRAE and CRVE, respectively were measured from digital retinal photographs. Diabetes was defined as physician-diagnosis of diabetes, self-reported use of diabetic medication, or fasting plasma glucose (FPG) ≥7 mmol/L; IFG as FPG 6.1-6.9 mmol/L. Results: After adjusting for age, gender, ethnicity, systolic blood pressure, body mass index, total cholesterol, triglycerides, smoking, and vascular caliber (Model 3), participants with diabetes had both larger CRAE and CRVE, compared to those with normal fasting glucose (NFG) or IFG. In a multivariate analysis, including clinical risk factors and CRVE, mean CRAE increased from 143.6 μm in NFG to 145.3 μm with diabetes (P for trend = 0.01). On the other hand, each mmol/L increase in FPG was associated with a 0.51-μm increase in CRVE (P=0.006). In a subgroup analysis stratified by ethnicity, the association between FPG and larger CRVE was predominantly present among ethnic Indians (0.9-μm increase in CRVE per mmol/L increase in FPG). Conclusion: Diabetes was associated with larger retinal arteriolar diameters and glucose level was associated with larger retinal venular diameters in this multiethnic Asian population. The magnitude of association between glucose level and venular widening was stronger among ethnic Indians.||Source Title:||Microcirculation||URI:||http://scholarbank.nus.edu.sg/handle/10635/108521||ISSN:||10739688||DOI:||10.1080/10739680902975222|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 17, 2019
WEB OF SCIENCETM
checked on Oct 17, 2019
checked on Oct 11, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.