Please use this identifier to cite or link to this item:
Title: Alcohol and aldehyde dehydrogenase polymorphisms in chinese and indian populations
Authors: Tan, E.-C. 
Lim, L.
Leong, J.-Y.
Lim, J.-Y.
Lee, A.
Yang, J.
Tan, C.-H.
Winslow, M.
Keywords: Alcohol dehydrogenase
Aldehyde dehydrogenase
Genetic polymorphisms
Issue Date: 2010
Citation: Tan, E.-C., Lim, L., Leong, J.-Y., Lim, J.-Y., Lee, A., Yang, J., Tan, C.-H., Winslow, M. (2010). Alcohol and aldehyde dehydrogenase polymorphisms in chinese and indian populations. Substance Use and Misuse 45 (1-2) : 1-14. ScholarBank@NUS Repository.
Abstract: The association between two functional polymorphisms in alcohol dehydrogenase (ADH2/ADH1B) and aldehyde dehydrogenase (ALDH2) genes and alcohol dependence was examined in 182 Chinese and Indian patients undergoing treatment for alcohol dependence and 184 screened control subjects from Singapore. All subjects were screened by the Alcohol Use Disorders Identification Test (AUDIT). Patients were also administered the Severity of Alcohol Dependence Questionnaire (SADQ). Polymorphisms were genotyped by allele-specific polymerase chain reaction and selected genotypes confirmed by DNA sequencing or restriction fragment length polymorphism. Our results showed that frequencies of ADH1B*2 and ALDH2*2 were higher in controls compared to alcohol-dependent subjects for both Chinese and Indians. Frequencies of these two alleles were also higher in the 104 Chinese controls compared to the 80 Indian controls. None of the eight Chinese who were homozygous for both protective alleles was alcohol dependent. The higher frequencies of the protective alleles could explain the lower rate of alcohol dependence in Chinese. © 2010 Informa Healthcare USA, Inc.
Source Title: Substance Use and Misuse
ISSN: 10826084
DOI: 10.3109/10826080802490584
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.