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Title: Herbimycin A attenuates apoptosis during heat stress in rats
Authors: Sachidhanandam, S.B.
Lu, J. 
Low, K.S.Y. 
Moochhala, S.M. 
Keywords: (Rat)
Heat shock protein
Herbimycin A
Issue Date: 1-Aug-2003
Citation: Sachidhanandam, S.B., Lu, J., Low, K.S.Y., Moochhala, S.M. (2003-08-01). Herbimycin A attenuates apoptosis during heat stress in rats. European Journal of Pharmacology 474 (1) : 121-128. ScholarBank@NUS Repository.
Abstract: Expression of heat shock proteins (HSPs) as a heat stress response is associated with acquisition of thermotolerance. Herbimycin A is a tyrosine kinase inhibitor that has been shown to induce HSPs. The present study aims to investigate the effects of herbimycin A on thermotolerance in rats subjected to heat stress exposure. Herbimycin A induced hsp70 to peak levels 12 h post-injection in rats without heat stress. No change in hsp70 levels was observed in the vehicle- and saline-treated rats. In rats exposed to heat stress at 45 °C for 25 min, 12 h post-treatment, lower peak temperatures were attained in herbimycin A-treated group as compared to the vehicle- and saline-treated groups. Terminal transferase-mediated d-UTP nick end labeling (TUNEL) showed that a significant decrease in apoptosis of hepatocytes in herbimycin A-treated rats as compared to the vehicle- and saline-treated rats. Caspase-3 activation was also lower in herbimycin A-treated rats, compared to the vehicle- and saline-treated rats. The present study has demonstrated that herbimycin A is effective for development of thermotolerance and therefore protects rats from heat stress. © 2003 Elsevier B.V. All rights reserved.
Source Title: European Journal of Pharmacology
ISSN: 00142999
DOI: 10.1016/S0014-2999(03)01997-6
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