Please use this identifier to cite or link to this item:
|dc.title||Herbimycin A attenuates apoptosis during heat stress in rats|
|dc.identifier.citation||Sachidhanandam, S.B., Lu, J., Low, K.S.Y., Moochhala, S.M. (2003-08-01). Herbimycin A attenuates apoptosis during heat stress in rats. European Journal of Pharmacology 474 (1) : 121-128. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-2999(03)01997-6|
|dc.description.abstract||Expression of heat shock proteins (HSPs) as a heat stress response is associated with acquisition of thermotolerance. Herbimycin A is a tyrosine kinase inhibitor that has been shown to induce HSPs. The present study aims to investigate the effects of herbimycin A on thermotolerance in rats subjected to heat stress exposure. Herbimycin A induced hsp70 to peak levels 12 h post-injection in rats without heat stress. No change in hsp70 levels was observed in the vehicle- and saline-treated rats. In rats exposed to heat stress at 45 °C for 25 min, 12 h post-treatment, lower peak temperatures were attained in herbimycin A-treated group as compared to the vehicle- and saline-treated groups. Terminal transferase-mediated d-UTP nick end labeling (TUNEL) showed that a significant decrease in apoptosis of hepatocytes in herbimycin A-treated rats as compared to the vehicle- and saline-treated rats. Caspase-3 activation was also lower in herbimycin A-treated rats, compared to the vehicle- and saline-treated rats. The present study has demonstrated that herbimycin A is effective for development of thermotolerance and therefore protects rats from heat stress. © 2003 Elsevier B.V. All rights reserved.|
|dc.subject||Heat shock protein|
|dc.description.sourcetitle||European Journal of Pharmacology|
|Appears in Collections:||Staff Publications|
Show simple item record
Files in This Item:
There are no files associated with this item.
checked on Jun 28, 2020
WEB OF SCIENCETM
checked on Jun 19, 2020
checked on Jun 27, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.