Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0014-2999(03)01997-6
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dc.titleHerbimycin A attenuates apoptosis during heat stress in rats
dc.contributor.authorSachidhanandam, S.B.
dc.contributor.authorLu, J.
dc.contributor.authorLow, K.S.Y.
dc.contributor.authorMoochhala, S.M.
dc.date.accessioned2014-11-20T05:58:49Z
dc.date.available2014-11-20T05:58:49Z
dc.date.issued2003-08-01
dc.identifier.citationSachidhanandam, S.B., Lu, J., Low, K.S.Y., Moochhala, S.M. (2003-08-01). Herbimycin A attenuates apoptosis during heat stress in rats. European Journal of Pharmacology 474 (1) : 121-128. ScholarBank@NUS Repository. https://doi.org/10.1016/S0014-2999(03)01997-6
dc.identifier.issn00142999
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108094
dc.description.abstractExpression of heat shock proteins (HSPs) as a heat stress response is associated with acquisition of thermotolerance. Herbimycin A is a tyrosine kinase inhibitor that has been shown to induce HSPs. The present study aims to investigate the effects of herbimycin A on thermotolerance in rats subjected to heat stress exposure. Herbimycin A induced hsp70 to peak levels 12 h post-injection in rats without heat stress. No change in hsp70 levels was observed in the vehicle- and saline-treated rats. In rats exposed to heat stress at 45 °C for 25 min, 12 h post-treatment, lower peak temperatures were attained in herbimycin A-treated group as compared to the vehicle- and saline-treated groups. Terminal transferase-mediated d-UTP nick end labeling (TUNEL) showed that a significant decrease in apoptosis of hepatocytes in herbimycin A-treated rats as compared to the vehicle- and saline-treated rats. Caspase-3 activation was also lower in herbimycin A-treated rats, compared to the vehicle- and saline-treated rats. The present study has demonstrated that herbimycin A is effective for development of thermotolerance and therefore protects rats from heat stress. © 2003 Elsevier B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0014-2999(03)01997-6
dc.sourceScopus
dc.subject(Rat)
dc.subjectApoptosis
dc.subjectHeat shock protein
dc.subjectHerbimycin A
dc.subjectThermotolerance
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentANATOMY
dc.description.doi10.1016/S0014-2999(03)01997-6
dc.description.sourcetitleEuropean Journal of Pharmacology
dc.description.volume474
dc.description.issue1
dc.description.page121-128
dc.description.codenEJPHA
dc.identifier.isiut000184819000015
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