Please use this identifier to cite or link to this item:
|Title:||Adenosine and its receptor agonists potentiate nitric oxide synthase expression induced by lipopolysaccharide in RAW 264.7 murine macrophages||Authors:||Hon, W.-M.
nitric oxide synthase
RAW 264.7 macrophage
|Issue Date:||14-Mar-1997||Citation:||Hon, W.-M., Moochhala, S., Khoo, H.-E. (1997-03-14). Adenosine and its receptor agonists potentiate nitric oxide synthase expression induced by lipopolysaccharide in RAW 264.7 murine macrophages. Life Sciences 60 (16) : 1327-1335. ScholarBank@NUS Repository. https://doi.org/10.1016/S0024-3205(97)00078-7||Abstract:||The effect of adenosine and its agonists on nitric oxide synthase (NOS) activity and the production of nitrite induced by lipopolysaccharide (LPS) in RAW 264.7 cells were investigated. Nitrite production and NOS activity in the RAW 264.7 cells were increased up to 2.5 fold after co-exposure of the cells to LPS and adenosine or its agonists, as compared to LPS alone. Adenosine and its agonists had no effect on NOS activity when incubated alone with RAW 264.7 cells. Enhancement caused by adenosine or its agonists was dose-dependent but the effect was neither A1 nor A2 receptor specific. These findings suggest that during pathological conditions such as inflammation or trauma, the significant amounts of cellular adenosine which are released may increase the production of NO by macrophage.||Source Title:||Life Sciences||URI:||http://scholarbank.nus.edu.sg/handle/10635/107789||ISSN:||00243205||DOI:||10.1016/S0024-3205(97)00078-7|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.