Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0024-3205(97)00078-7
Title: Adenosine and its receptor agonists potentiate nitric oxide synthase expression induced by lipopolysaccharide in RAW 264.7 murine macrophages
Authors: Hon, W.-M.
Moochhala, S. 
Khoo, H.-E. 
Keywords: adenosine
nitric oxide synthase
RAW 264.7 macrophage
Issue Date: 14-Mar-1997
Citation: Hon, W.-M., Moochhala, S., Khoo, H.-E. (1997-03-14). Adenosine and its receptor agonists potentiate nitric oxide synthase expression induced by lipopolysaccharide in RAW 264.7 murine macrophages. Life Sciences 60 (16) : 1327-1335. ScholarBank@NUS Repository. https://doi.org/10.1016/S0024-3205(97)00078-7
Abstract: The effect of adenosine and its agonists on nitric oxide synthase (NOS) activity and the production of nitrite induced by lipopolysaccharide (LPS) in RAW 264.7 cells were investigated. Nitrite production and NOS activity in the RAW 264.7 cells were increased up to 2.5 fold after co-exposure of the cells to LPS and adenosine or its agonists, as compared to LPS alone. Adenosine and its agonists had no effect on NOS activity when incubated alone with RAW 264.7 cells. Enhancement caused by adenosine or its agonists was dose-dependent but the effect was neither A1 nor A2 receptor specific. These findings suggest that during pathological conditions such as inflammation or trauma, the significant amounts of cellular adenosine which are released may increase the production of NO by macrophage.
Source Title: Life Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/107789
ISSN: 00243205
DOI: 10.1016/S0024-3205(97)00078-7
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