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|Title:||Synthesis and in vitro antimalarial activity of some indolo[3,2-c]quinolines||Authors:||Go, M.
|Keywords:||in vitro antimalarial activity
|Issue Date:||Jun-1992||Citation:||Go, M.,Koh, H.,Ngiam, T.,Phillipson, J.,Kirby, G.,O'Neill, M.,Warhurs, D. (1992-06). Synthesis and in vitro antimalarial activity of some indolo[3,2-c]quinolines. European Journal of Medicinal Chemistry 27 (4) : 391-394. ScholarBank@NUS Repository.||Abstract:||A series of indolo[3,2-c]quinolines (1b-e) was synthesized by Fischer indolization of 7-chloro-1,2,3,4-tetrahydroquinolin-4-one with the appropriate hydrazines (7b-e). Evaluation of in vitro antimalarial activity was carried out against a chloroquine resistant strain of Plasmodium falciparum. Except for compound 1e which lacked a basic side chain at position 9, the other indolo[3,2-c]quinolines 1b-d were active. The most active compound was 3-chloro-8-methoxy-9-(4-methyl-1-piperazinylmethyl)-11H-indolo[3,2-c]quinoline (1d) trihydrochloride which was about 104 times more active than chloroquine in vitro. The effects of structural variation on antimalarial activity were discussed. © 1992.||Source Title:||European Journal of Medicinal Chemistry||URI:||http://scholarbank.nus.edu.sg/handle/10635/106394||ISSN:||02235234|
|Appears in Collections:||Staff Publications|
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