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Title: Synthesis and in vitro antimalarial activity of some indolo[3,2-c]quinolines
Authors: Go, M. 
Koh, H. 
Ngiam, T. 
Phillipson, J.
Kirby, G.
O'Neill, M.
Warhurs, D.
Keywords: in vitro antimalarial activity
Issue Date: Jun-1992
Citation: Go, M.,Koh, H.,Ngiam, T.,Phillipson, J.,Kirby, G.,O'Neill, M.,Warhurs, D. (1992-06). Synthesis and in vitro antimalarial activity of some indolo[3,2-c]quinolines. European Journal of Medicinal Chemistry 27 (4) : 391-394. ScholarBank@NUS Repository.
Abstract: A series of indolo[3,2-c]quinolines (1b-e) was synthesized by Fischer indolization of 7-chloro-1,2,3,4-tetrahydroquinolin-4-one with the appropriate hydrazines (7b-e). Evaluation of in vitro antimalarial activity was carried out against a chloroquine resistant strain of Plasmodium falciparum. Except for compound 1e which lacked a basic side chain at position 9, the other indolo[3,2-c]quinolines 1b-d were active. The most active compound was 3-chloro-8-methoxy-9-(4-methyl-1-piperazinylmethyl)-11H-indolo[3,2-c]quinoline (1d) trihydrochloride which was about 104 times more active than chloroquine in vitro. The effects of structural variation on antimalarial activity were discussed. © 1992.
Source Title: European Journal of Medicinal Chemistry
ISSN: 02235234
Appears in Collections:Staff Publications

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