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|Title:||Sesquiterpene lactones from Ixeris sonchifolia Hance and their cytotoxicities on A549 human non-small cell lung cancer cells||Authors:||Zhang, Y.-C.
Ixeris sonchifolia hance
|Issue Date:||Apr-2009||Citation:||Zhang, Y.-C., Zhou, L., Ng, K.-Y. (2009-04). Sesquiterpene lactones from Ixeris sonchifolia Hance and their cytotoxicities on A549 human non-small cell lung cancer cells. Journal of Asian Natural Products Research 11 (4) : 294-298. ScholarBank@NUS Repository. https://doi.org/10.1080/10286020902727520||Abstract:||A new sesquiterpene lactone glucoside, 11,13-dihydroixerinoside (1), together with the five known sesquiterpene lactones, ixerinoside (2), ixerin Z (3), 11,13-dihydroixerin Z (4), ixerin Z1 (5), and 3-hydroxydehydroleucodin (6), respectively, were isolated from the whole plants of Ixeris sonchifolia Hance. The compounds were identified by spectral analysis and comparison with spectroscopic data reported in the literatures. When the in vitro cytotoxic activities of compounds 1-6 were evaluated against A549 human non-small cell lung cancer cells, all six compounds exhibited cytotoxic activity against A549 cells, with compounds 2, 3, and 6 showing good activities (inhibitory concentration (IC50 values 30g/ml) that are comparable with well-established chemotherapeutic drug, 5-fluorouracil.||Source Title:||Journal of Asian Natural Products Research||URI:||http://scholarbank.nus.edu.sg/handle/10635/106330||ISSN:||10286020||DOI:||10.1080/10286020902727520|
|Appears in Collections:||Staff Publications|
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