Please use this identifier to cite or link to this item: https://doi.org/10.1080/10286020902727520
Title: Sesquiterpene lactones from Ixeris sonchifolia Hance and their cytotoxicities on A549 human non-small cell lung cancer cells
Authors: Zhang, Y.-C.
Zhou, L. 
Ng, K.-Y. 
Keywords: 11,13-dihydroixerinoside
A549
Cytotoxicity
Ixeris sonchifolia hance
Sesquiterpene lactones
Issue Date: Apr-2009
Citation: Zhang, Y.-C., Zhou, L., Ng, K.-Y. (2009-04). Sesquiterpene lactones from Ixeris sonchifolia Hance and their cytotoxicities on A549 human non-small cell lung cancer cells. Journal of Asian Natural Products Research 11 (4) : 294-298. ScholarBank@NUS Repository. https://doi.org/10.1080/10286020902727520
Abstract: A new sesquiterpene lactone glucoside, 11,13-dihydroixerinoside (1), together with the five known sesquiterpene lactones, ixerinoside (2), ixerin Z (3), 11,13-dihydroixerin Z (4), ixerin Z1 (5), and 3-hydroxydehydroleucodin (6), respectively, were isolated from the whole plants of Ixeris sonchifolia Hance. The compounds were identified by spectral analysis and comparison with spectroscopic data reported in the literatures. When the in vitro cytotoxic activities of compounds 1-6 were evaluated against A549 human non-small cell lung cancer cells, all six compounds exhibited cytotoxic activity against A549 cells, with compounds 2, 3, and 6 showing good activities (inhibitory concentration (IC50 values 30g/ml) that are comparable with well-established chemotherapeutic drug, 5-fluorouracil.
Source Title: Journal of Asian Natural Products Research
URI: http://scholarbank.nus.edu.sg/handle/10635/106330
ISSN: 10286020
DOI: 10.1080/10286020902727520
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