Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.rinphs.2011.10.002
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dc.titleNanosized ethosomes bearing ketoprofen for improved transdermal delivery
dc.contributor.authorChourasia, M.K.
dc.contributor.authorKang, L.
dc.contributor.authorChan, S.Y.
dc.date.accessioned2014-10-29T01:56:03Z
dc.date.available2014-10-29T01:56:03Z
dc.date.issued2011
dc.identifier.citationChourasia, M.K.,Kang, L.,Chan, S.Y. (2011). Nanosized ethosomes bearing ketoprofen for improved transdermal delivery. Results in Pharma Sciences 1 (1) : 60-67. ScholarBank@NUS Repository. <a href="https://doi.org/10.1016/j.rinphs.2011.10.002" target="_blank">https://doi.org/10.1016/j.rinphs.2011.10.002</a>
dc.identifier.issn22112863
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106165
dc.description.abstractThe potential of ethosomes for delivering ketoprofen via skin was evaluated. The ethosomes were prepared, optimized and characterized. Vesicular shape, size and entrapment efficiency were determined by transmission electron microscopy, dynamic light scattering and minicolumn centrifugation technique, respectively. Vesicle sizes varied from 120.3 7 6.1 to 410.2721.8 nm depending on the concentrations of soya phosphatidyl choline (SPC) and ethanol. Entrapment efficiency increased with concentrations of SPC and ethanol. The formulations exhibited entrapment efficiencies of 42-78%. In vitro release through cellophane membrane showed sustained release of drug from ethosomal formulations in contrast to hydroalcoholic drug solution (HA), which released most of the drug within 2-3 h. In vitro drug permeation across human skin revealed improved drug permeation and higher transdermal flux with ethosomal formulations compared to hydroethanolic drug solution. Kinetics of in vitro skin permeation showed zero order drug release from formulations. Based on in vitro transdermal flux, the estimated steady state in vivo plasma concentration from ethosomes attained therapeutic drug levels whereas hydroalcoholic drug solution exhibited sub therapeutic drug concentration with a patch size of 50 cm 2. Skin permeation of ethosomal formulations assessed by confocal microscopy revealed enhanced permeation of Rhodamine 123 loaded formulation in comparison to the hydroalcoholic solution. © 2011 Elsevier B.V.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.rinphs.2011.10.002
dc.sourceScopus
dc.subjectConfocal microscopy
dc.subjectEthosomes
dc.subjectIn vitro skin permeation
dc.subjectKetoprofen
dc.subjectTransdermal delivery
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1016/j.rinphs.2011.10.002
dc.description.sourcetitleResults in Pharma Sciences
dc.description.volume1
dc.description.issue1
dc.description.page60-67
dc.identifier.isiutNOT_IN_WOS
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