Information of ADME-associated proteins and potential application for pharmacogenetic prediction of drug responses

Abstract

Pharmacogenetic prediction and mechanistic elucidation of individual variations of drug response is important for facilitating the development of personalized medicines and optimum therapeutic dosages. One of the keys to pharmacogenetic studies is the knowledge about proteins responsible for the absorption, distribution, metabolism and excretion (ADME) of drugs. This article describes the web-resources of ADME-associated proteins, assesses the usefulness of the relevant information for facilitating pharmacogenetic prediction of drug responses, and discusses computational methods that explore the relevant information for predicting individual variations of drug response from the polymorphisms of ADME-associated proteins. ©2006 Bentham Science Publishers Ltd.