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Title: Information of ADME-associated proteins and potential application for pharmacogenetic prediction of drug responses
Authors: Zheng, C.J. 
Han, L.Y. 
Chen, X.
Cao, Z.W.
Cui, J.
Lin, H.H.
Zhang, H.L.
Li, H. 
Chen, Y.Z. 
Keywords: Carrier
Drug design
Drug development
Drug discovery
Drug metabolizing enzyme
Drug target
Ligand-binding protein
Issue Date: Jun-2006
Source: Zheng, C.J.,Han, L.Y.,Chen, X.,Cao, Z.W.,Cui, J.,Lin, H.H.,Zhang, H.L.,Li, H.,Chen, Y.Z. (2006-06). Information of ADME-associated proteins and potential application for pharmacogenetic prediction of drug responses. Current Pharmacogenomics 4 (2) : 87-103. ScholarBank@NUS Repository.
Abstract: Pharmacogenetic prediction and mechanistic elucidation of individual variations of drug response is important for facilitating the development of personalized medicines and optimum therapeutic dosages. One of the keys to pharmacogenetic studies is the knowledge about proteins responsible for the absorption, distribution, metabolism and excretion (ADME) of drugs. This article describes the web-resources of ADME-associated proteins, assesses the usefulness of the relevant information for facilitating pharmacogenetic prediction of drug responses, and discusses computational methods that explore the relevant information for predicting individual variations of drug response from the polymorphisms of ADME-associated proteins. ©2006 Bentham Science Publishers Ltd.
Source Title: Current Pharmacogenomics
ISSN: 15701603
DOI: 10.2174/157016006776286819
Appears in Collections:Staff Publications

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