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Title: Influence of production variables on the sphericity of melt pellets
Authors: Heng, P.W.S. 
Wong, T.W. 
Chan, L.W. 
Keywords: Energy
High shear mixer
Melt pelletization
Issue Date: Mar-2000
Citation: Heng, P.W.S.,Wong, T.W.,Chan, L.W. (2000-03). Influence of production variables on the sphericity of melt pellets. Chemical and Pharmaceutical Bulletin 48 (3) : 420-424. ScholarBank@NUS Repository.
Abstract: This paper reports the influence of post-melt impeller speed, post-melt processing time, binder concentration and particle size of bulk material on the sphericity of pellets produced by melt pelletization in a high shear mixer. Lactose was used as the bulk material with polyethylene glycol 3000 as a meltable binder. Time sphericity of pellets was found to be affected by post-melt impeller speed and post-melt processing time. Binder concentration and particle size of bulk material had a lesser effect on pellet sphericity. The melt pelletization process can be divided into two spheronization phases (a fast initial rate, followed by a slower rate). The change in the spheronization rate was associated with time pellet size, porosity and flow pattern of time processing material. The present study established a bi- exponential mathematical model to relate the pellet sphericity with post-melt specific energy consumption. The relationship of pellet sphericity with post- melt specific energy consumption was independent of the effects of the production variables.
Source Title: Chemical and Pharmaceutical Bulletin
ISSN: 00092363
Appears in Collections:Staff Publications

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