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|Title:||Influence of production variables on the sphericity of melt pellets||Authors:||Heng, P.W.S.
High shear mixer
|Issue Date:||Mar-2000||Citation:||Heng, P.W.S.,Wong, T.W.,Chan, L.W. (2000-03). Influence of production variables on the sphericity of melt pellets. Chemical and Pharmaceutical Bulletin 48 (3) : 420-424. ScholarBank@NUS Repository.||Abstract:||This paper reports the influence of post-melt impeller speed, post-melt processing time, binder concentration and particle size of bulk material on the sphericity of pellets produced by melt pelletization in a high shear mixer. Lactose was used as the bulk material with polyethylene glycol 3000 as a meltable binder. Time sphericity of pellets was found to be affected by post-melt impeller speed and post-melt processing time. Binder concentration and particle size of bulk material had a lesser effect on pellet sphericity. The melt pelletization process can be divided into two spheronization phases (a fast initial rate, followed by a slower rate). The change in the spheronization rate was associated with time pellet size, porosity and flow pattern of time processing material. The present study established a bi- exponential mathematical model to relate the pellet sphericity with post-melt specific energy consumption. The relationship of pellet sphericity with post- melt specific energy consumption was independent of the effects of the production variables.||Source Title:||Chemical and Pharmaceutical Bulletin||URI:||http://scholarbank.nus.edu.sg/handle/10635/106053||ISSN:||00092363|
|Appears in Collections:||Staff Publications|
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