Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/106053
DC FieldValue
dc.titleInfluence of production variables on the sphericity of melt pellets
dc.contributor.authorHeng, P.W.S.
dc.contributor.authorWong, T.W.
dc.contributor.authorChan, L.W.
dc.date.accessioned2014-10-29T01:54:20Z
dc.date.available2014-10-29T01:54:20Z
dc.date.issued2000-03
dc.identifier.citationHeng, P.W.S., Wong, T.W., Chan, L.W. (2000-03). Influence of production variables on the sphericity of melt pellets. Chemical and Pharmaceutical Bulletin 48 (3) : 420-424. ScholarBank@NUS Repository.
dc.identifier.issn00092363
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106053
dc.description.abstractThis paper reports the influence of post-melt impeller speed, post-melt processing time, binder concentration and particle size of bulk material on the sphericity of pellets produced by melt pelletization in a high shear mixer. Lactose was used as the bulk material with polyethylene glycol 3000 as a meltable binder. Time sphericity of pellets was found to be affected by post-melt impeller speed and post-melt processing time. Binder concentration and particle size of bulk material had a lesser effect on pellet sphericity. The melt pelletization process can be divided into two spheronization phases (a fast initial rate, followed by a slower rate). The change in the spheronization rate was associated with time pellet size, porosity and flow pattern of time processing material. The present study established a bi- exponential mathematical model to relate the pellet sphericity with post-melt specific energy consumption. The relationship of pellet sphericity with post- melt specific energy consumption was independent of the effects of the production variables.
dc.sourceScopus
dc.subjectEnergy
dc.subjectHigh shear mixer
dc.subjectMelt pelletization
dc.subjectSphericity
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.sourcetitleChemical and Pharmaceutical Bulletin
dc.description.volume48
dc.description.issue3
dc.description.page420-424
dc.description.codenCPBTA
dc.identifier.isiutNOT_IN_WOS
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