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Title: Drug release from heat-treated polyvinyl alcohol films
Authors: Wan, L.S.C. 
Lim, L.Y. 
Issue Date: 1992
Citation: Wan, L.S.C.,Lim, L.Y. (1992). Drug release from heat-treated polyvinyl alcohol films. Drug Development and Industrial Pharmacy 18 (17) : 1895-1906. ScholarBank@NUS Repository.
Abstract: Polyvinyl alcohol (PVA) films containing 10% w/w of a model drug, sulphathiazole, were cast from aqueous solutions and subjected to heat treatment at specific temperatures for known periods of time. Heat treatment at temperatures above the T(g) of the PVA films slowed down the rate of drug release from the films. Increasing the temperature of heat treatment from 120°C to 160°C further decreased the rate of drug release. On the other hand, if the heat treatment were conducted at a temperature below the T(g) e.g. at 80°C, there were insignificant differences between the release profile of sulphathiazole from heat-treated films and that from untreated films. The duration of heat treatment affected the rate of drug release to a smaller extent compared to the temperature of heat treatment. These results correlated with the heat induced changes in the morphology of, and in the extent of water uptake by the PVA films.
Source Title: Drug Development and Industrial Pharmacy
ISSN: 03639045
Appears in Collections:Staff Publications

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