Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/105856
DC FieldValue
dc.titleDrug release from heat-treated polyvinyl alcohol films
dc.contributor.authorWan, L.S.C.
dc.contributor.authorLim, L.Y.
dc.date.accessioned2014-10-29T01:51:39Z
dc.date.available2014-10-29T01:51:39Z
dc.date.issued1992
dc.identifier.citationWan, L.S.C.,Lim, L.Y. (1992). Drug release from heat-treated polyvinyl alcohol films. Drug Development and Industrial Pharmacy 18 (17) : 1895-1906. ScholarBank@NUS Repository.
dc.identifier.issn03639045
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105856
dc.description.abstractPolyvinyl alcohol (PVA) films containing 10% w/w of a model drug, sulphathiazole, were cast from aqueous solutions and subjected to heat treatment at specific temperatures for known periods of time. Heat treatment at temperatures above the T(g) of the PVA films slowed down the rate of drug release from the films. Increasing the temperature of heat treatment from 120°C to 160°C further decreased the rate of drug release. On the other hand, if the heat treatment were conducted at a temperature below the T(g) e.g. at 80°C, there were insignificant differences between the release profile of sulphathiazole from heat-treated films and that from untreated films. The duration of heat treatment affected the rate of drug release to a smaller extent compared to the temperature of heat treatment. These results correlated with the heat induced changes in the morphology of, and in the extent of water uptake by the PVA films.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.sourcetitleDrug Development and Industrial Pharmacy
dc.description.volume18
dc.description.issue17
dc.description.page1895-1906
dc.description.codenDDIPD
dc.identifier.isiutNOT_IN_WOS
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