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Title: Application of multidimensional scaling to preformulation sciences: A discriminatory tool to group microcrystalline celluloses
Authors: Liew, C.V. 
Soh, J.L.P.
Chen, F.
Shi, D.
Heng, P.W.S. 
Keywords: Microcrystalline cellulose (MCC)
Multidimensional scaling (MDS)
Rheological property
Issue Date: Oct-2005
Citation: Liew, C.V., Soh, J.L.P., Chen, F., Shi, D., Heng, P.W.S. (2005-10). Application of multidimensional scaling to preformulation sciences: A discriminatory tool to group microcrystalline celluloses. Chemical and Pharmaceutical Bulletin 53 (10) : 1227-1231. ScholarBank@NUS Repository.
Abstract: Pre-formulation studies constitute the first step of any pharmaceutical product development and manufacture. Establishment of a comprehensive library of critical physical, chemical, biological and mechanical properties of all materials used for a formulation can be costly, tedious and time consuming, despite its importance in quality manufacturing management. This study seeks to demonstrate the pharmaceutical application of multidimensional scaling (MDS) by incorporating it as a pre-formulation tool for grouping an expanded range of microcrystalline celluloses (MCC). MDS presents the various MCC grades in two-dimensional space based on their torque rheological properties; thus conferring an extra dimension to the pre-formulation tool to facilitate the visualization of the relative positions of each MCC grade. Through this work, the utility of MDS for expediting pre-formulation studies, in particular, grouping of excipients that are available in different brands and grades can be amply exemplified. © 2005 Pharmaceutical Society of Japan.
Source Title: Chemical and Pharmaceutical Bulletin
ISSN: 00092363
DOI: 10.1248/cpb.53.1227
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