Please use this identifier to cite or link to this item: https://doi.org/10.1248/cpb.53.1227
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dc.titleApplication of multidimensional scaling to preformulation sciences: A discriminatory tool to group microcrystalline celluloses
dc.contributor.authorLiew, C.V.
dc.contributor.authorSoh, J.L.P.
dc.contributor.authorChen, F.
dc.contributor.authorShi, D.
dc.contributor.authorHeng, P.W.S.
dc.date.accessioned2014-10-29T01:48:52Z
dc.date.available2014-10-29T01:48:52Z
dc.date.issued2005-10
dc.identifier.citationLiew, C.V., Soh, J.L.P., Chen, F., Shi, D., Heng, P.W.S. (2005-10). Application of multidimensional scaling to preformulation sciences: A discriminatory tool to group microcrystalline celluloses. Chemical and Pharmaceutical Bulletin 53 (10) : 1227-1231. ScholarBank@NUS Repository. https://doi.org/10.1248/cpb.53.1227
dc.identifier.issn00092363
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105670
dc.description.abstractPre-formulation studies constitute the first step of any pharmaceutical product development and manufacture. Establishment of a comprehensive library of critical physical, chemical, biological and mechanical properties of all materials used for a formulation can be costly, tedious and time consuming, despite its importance in quality manufacturing management. This study seeks to demonstrate the pharmaceutical application of multidimensional scaling (MDS) by incorporating it as a pre-formulation tool for grouping an expanded range of microcrystalline celluloses (MCC). MDS presents the various MCC grades in two-dimensional space based on their torque rheological properties; thus conferring an extra dimension to the pre-formulation tool to facilitate the visualization of the relative positions of each MCC grade. Through this work, the utility of MDS for expediting pre-formulation studies, in particular, grouping of excipients that are available in different brands and grades can be amply exemplified. © 2005 Pharmaceutical Society of Japan.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1248/cpb.53.1227
dc.sourceScopus
dc.subjectMicrocrystalline cellulose (MCC)
dc.subjectMultidimensional scaling (MDS)
dc.subjectPre-formulation
dc.subjectRheological property
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1248/cpb.53.1227
dc.description.sourcetitleChemical and Pharmaceutical Bulletin
dc.description.volume53
dc.description.issue10
dc.description.page1227-1231
dc.description.codenCPBTA
dc.identifier.isiut000232679900002
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