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Title: A study on microwave-induced melt granulation in a single pot high shear processor
Authors: Liew, C.V. 
Loh, Z.H. 
Heng, P.W.S. 
Lee, C.C.
Keywords: High shear melt granulation
Mixer power consumption
Process control
Product temperature
Single pot processor
Issue Date: Sep-2008
Citation: Liew, C.V., Loh, Z.H., Heng, P.W.S., Lee, C.C. (2008-09). A study on microwave-induced melt granulation in a single pot high shear processor. Pharmaceutical Development and Technology 13 (5) : 401-411. ScholarBank@NUS Repository.
Abstract: Microwave-induced high shear melt granulation was compared with conventional melt granulation performed in the same processor. Admixtures of lactose 200M and anhydrous dicalcium phosphate were granulated with polyethylene glycol 3350. Different heating mechanisms in the two processes necessitated the use of different parameters for process monitoring and control. Mixer power consumption was suitable for monitoring agglomerate growth under microwave-induced heating. Product temperature was a better indicator of agglomeration propensity in conventional melt granulation. These were attributed to the disparities in heat acquisition rates and heating uniformities of the powders as well as variation in baseline mixer power consumption between the two processes. Copyright © Informa UK, Ltd.
Source Title: Pharmaceutical Development and Technology
ISSN: 10837450
DOI: 10.1080/10837450802244926
Appears in Collections:Staff Publications

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