Please use this identifier to cite or link to this item: https://doi.org/10.1080/10837450802244926
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dc.titleA study on microwave-induced melt granulation in a single pot high shear processor
dc.contributor.authorLiew, C.V.
dc.contributor.authorLoh, Z.H.
dc.contributor.authorHeng, P.W.S.
dc.contributor.authorLee, C.C.
dc.date.accessioned2014-10-29T01:47:57Z
dc.date.available2014-10-29T01:47:57Z
dc.date.issued2008-09
dc.identifier.citationLiew, C.V., Loh, Z.H., Heng, P.W.S., Lee, C.C. (2008-09). A study on microwave-induced melt granulation in a single pot high shear processor. Pharmaceutical Development and Technology 13 (5) : 401-411. ScholarBank@NUS Repository. https://doi.org/10.1080/10837450802244926
dc.identifier.issn10837450
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105603
dc.description.abstractMicrowave-induced high shear melt granulation was compared with conventional melt granulation performed in the same processor. Admixtures of lactose 200M and anhydrous dicalcium phosphate were granulated with polyethylene glycol 3350. Different heating mechanisms in the two processes necessitated the use of different parameters for process monitoring and control. Mixer power consumption was suitable for monitoring agglomerate growth under microwave-induced heating. Product temperature was a better indicator of agglomeration propensity in conventional melt granulation. These were attributed to the disparities in heat acquisition rates and heating uniformities of the powders as well as variation in baseline mixer power consumption between the two processes. Copyright © Informa UK, Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1080/10837450802244926
dc.sourceScopus
dc.subjectHigh shear melt granulation
dc.subjectMicrowave
dc.subjectMixer power consumption
dc.subjectProcess control
dc.subjectProduct temperature
dc.subjectSingle pot processor
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1080/10837450802244926
dc.description.sourcetitlePharmaceutical Development and Technology
dc.description.volume13
dc.description.issue5
dc.description.page401-411
dc.description.codenPDTEF
dc.identifier.isiut000259813600008
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