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Title: Some results on two-stage clinical trials
Authors: Chen, Y.-M.
Chen, G.-J.
Bai, Z.-D. 
Hu, F.-F. 
Keywords: Adaptive design
Bayesian method
Clinical trials
Optimal stopping time
Two-stage method
Issue Date: 2003
Citation: Chen, Y.-M.,Chen, G.-J.,Bai, Z.-D.,Hu, F.-F. (2003). Some results on two-stage clinical trials. Acta Mathematicae Applicatae Sinica 19 (3) : 447-458. ScholarBank@NUS Repository.
Abstract: Among a variety of adaptive designs, stage-wise design, especially, two-stage design is an important one because patient responses are not available immediately but are available in batches or intermittently in some situations. In this paper, by Bayesian method, the general formula of asymptotical optimal worth is given, meanwhile the length of some optimal designs at first stage concerning two-stage trials in several important cases has been obtained. © Springer-Verlag 2003.
Source Title: Acta Mathematicae Applicatae Sinica
ISSN: 01689673
DOI: 10.1007/s10255-003-0120-4
Appears in Collections:Staff Publications

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