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|Title:||Snake venom prothrombin activators similar to blood coagulation factor Xa||Authors:||Joseph, J.S.
Manjunatha Kini, R.
|Issue Date:||Dec-2004||Citation:||Joseph, J.S.,Manjunatha Kini, R. (2004-12). Snake venom prothrombin activators similar to blood coagulation factor Xa. Current Drug Targets - Cardiovascular and Haematological Disorders 4 (4) : 397-416. ScholarBank@NUS Repository. https://doi.org/10.2174/1568006043335781||Abstract:||Activation of prothrombin to mature thrombin in vivo occurs by the pro'eolytic action of the prothrombinase complex consisting of serine proteinase factor Xa, and cofactors that include factor Va, Ca2+ ions and phospholipids. Several exogenous prothrombin activators are found in snake venom. Among these, Group C prothrombin activators resemble the factor Xa-factor Va complex, while Group D activators are structurally and functionally similar to factor Xa. This review provides a detailed description of current knowledge on Group D prothrombin activators and highlights the importance of studying this family of proteins in enhancing our understanding of structure-function relationships in the mammalian prothrombinase complex. © 2004 Bentham Science Publishers Ltd.||Source Title:||Current Drug Targets - Cardiovascular and Haematological Disorders||URI:||http://scholarbank.nus.edu.sg/handle/10635/102544||ISSN:||15680061||DOI:||10.2174/1568006043335781|
|Appears in Collections:||Staff Publications|
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