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Please use this identifier to cite or link to this item: https://doi.org/10.2174/1568006043335781
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dc.titleSnake venom prothrombin activators similar to blood coagulation factor Xa
dc.contributor.authorJoseph, J.S.
dc.contributor.authorManjunatha Kini, R.
dc.date.accessioned2014-10-27T08:49:21Z
dc.date.available2014-10-27T08:49:21Z
dc.date.issued2004-12
dc.identifier.citationJoseph, J.S.,Manjunatha Kini, R. (2004-12). Snake venom prothrombin activators similar to blood coagulation factor Xa. Current Drug Targets - Cardiovascular and Haematological Disorders 4 (4) : 397-416. ScholarBank@NUS Repository. <a href="https://doi.org/10.2174/1568006043335781" target="_blank">https://doi.org/10.2174/1568006043335781</a>
dc.identifier.issn15680061
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/102544
dc.description.abstractActivation of prothrombin to mature thrombin in vivo occurs by the pro'eolytic action of the prothrombinase complex consisting of serine proteinase factor Xa, and cofactors that include factor Va, Ca2+ ions and phospholipids. Several exogenous prothrombin activators are found in snake venom. Among these, Group C prothrombin activators resemble the factor Xa-factor Va complex, while Group D activators are structurally and functionally similar to factor Xa. This review provides a detailed description of current knowledge on Group D prothrombin activators and highlights the importance of studying this family of proteins in enhancing our understanding of structure-function relationships in the mammalian prothrombinase complex. © 2004 Bentham Science Publishers Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.2174/1568006043335781
dc.sourceScopus
dc.subjectAnticoagulant
dc.subjectBlood clotting
dc.subjectFactor Xa
dc.subjectHopsarin D
dc.subjectNotecarin D
dc.subjectProthrombin activator
dc.subjectProthrombinase complex
dc.subjectSerine proteinase
dc.subjectSnake venom
dc.subjectTrocarin D
dc.typeReview
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.2174/1568006043335781
dc.description.sourcetitleCurrent Drug Targets - Cardiovascular and Haematological Disorders
dc.description.volume4
dc.description.issue4
dc.description.page397-416
dc.description.codenCDTCB
dc.identifier.isiutNOT_IN_WOS
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