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Title: Snake venom prothrombin activators similar to blood coagulation factor Xa
Authors: Joseph, J.S.
Manjunatha Kini, R. 
Keywords: Anticoagulant
Blood clotting
Factor Xa
Hopsarin D
Notecarin D
Prothrombin activator
Prothrombinase complex
Serine proteinase
Snake venom
Trocarin D
Issue Date: Dec-2004
Citation: Joseph, J.S.,Manjunatha Kini, R. (2004-12). Snake venom prothrombin activators similar to blood coagulation factor Xa. Current Drug Targets - Cardiovascular and Haematological Disorders 4 (4) : 397-416. ScholarBank@NUS Repository.
Abstract: Activation of prothrombin to mature thrombin in vivo occurs by the pro'eolytic action of the prothrombinase complex consisting of serine proteinase factor Xa, and cofactors that include factor Va, Ca2+ ions and phospholipids. Several exogenous prothrombin activators are found in snake venom. Among these, Group C prothrombin activators resemble the factor Xa-factor Va complex, while Group D activators are structurally and functionally similar to factor Xa. This review provides a detailed description of current knowledge on Group D prothrombin activators and highlights the importance of studying this family of proteins in enhancing our understanding of structure-function relationships in the mammalian prothrombinase complex. © 2004 Bentham Science Publishers Ltd.
Source Title: Current Drug Targets - Cardiovascular and Haematological Disorders
ISSN: 15680061
DOI: 10.2174/1568006043335781
Appears in Collections:Staff Publications

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