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Title: In vivo antimalarial activity of the beta-carboline alkaloid manzamine A
Authors: Ang, K.K.H.
Holmes, M.J. 
Higa, T.
Hamann, M.T.
Kara, U.A.K. 
Issue Date: 2000
Citation: Ang, K.K.H., Holmes, M.J., Higa, T., Hamann, M.T., Kara, U.A.K. (2000). In vivo antimalarial activity of the beta-carboline alkaloid manzamine A. Antimicrobial Agents and Chemotherapy 44 (6) : 1645-1649. ScholarBank@NUS Repository.
Abstract: Manzamine A, a β-carboline alkaloid present in several marine sponge species, inhibits the growth of the rodent malaria parasite Plasmodium berghei in vivo. More than 90% of the asexual erythrocytic stages of P. berghei were inhibited after a single intraperitoneal injection of manzamine A into infected mice. A remarkable aspect of manzamine A treatment is its ability to prolong the survival of highly parasitemic mice, with 40% recovery 60 days after a single injection. Oral administration of an oil suspension of manzamine A also produced significant reductions in parasitemia. The plasma manzamine A concentration peaked 4 h after injection and remained high even at 48 h. Morphological changes of P. berghei were observed 1 h after treatment of infected mice. (-)-8-Hydroxymanzamine A also displayed antimalarial activity, whereas manzamine F, a ketone analog of manzamine A, did not. Our results suggest that manzamine A and (-)-8-hydroxymanzamine A are promising new antimalarial agents.
Source Title: Antimicrobial Agents and Chemotherapy
ISSN: 00664804
DOI: 10.1128/AAC.44.6.1645-1649.2000
Appears in Collections:Staff Publications

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