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|Title:||In vivo antimalarial activity of the beta-carboline alkaloid manzamine A||Authors:||Ang, K.K.H.
|Issue Date:||2000||Citation:||Ang, K.K.H., Holmes, M.J., Higa, T., Hamann, M.T., Kara, U.A.K. (2000). In vivo antimalarial activity of the beta-carboline alkaloid manzamine A. Antimicrobial Agents and Chemotherapy 44 (6) : 1645-1649. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.44.6.1645-1649.2000||Abstract:||Manzamine A, a β-carboline alkaloid present in several marine sponge species, inhibits the growth of the rodent malaria parasite Plasmodium berghei in vivo. More than 90% of the asexual erythrocytic stages of P. berghei were inhibited after a single intraperitoneal injection of manzamine A into infected mice. A remarkable aspect of manzamine A treatment is its ability to prolong the survival of highly parasitemic mice, with 40% recovery 60 days after a single injection. Oral administration of an oil suspension of manzamine A also produced significant reductions in parasitemia. The plasma manzamine A concentration peaked 4 h after injection and remained high even at 48 h. Morphological changes of P. berghei were observed 1 h after treatment of infected mice. (-)-8-Hydroxymanzamine A also displayed antimalarial activity, whereas manzamine F, a ketone analog of manzamine A, did not. Our results suggest that manzamine A and (-)-8-hydroxymanzamine A are promising new antimalarial agents.||Source Title:||Antimicrobial Agents and Chemotherapy||URI:||http://scholarbank.nus.edu.sg/handle/10635/100905||ISSN:||00664804||DOI:||10.1128/AAC.44.6.1645-1649.2000|
|Appears in Collections:||Staff Publications|
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