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https://doi.org/10.1128/AAC.44.6.1645-1649.2000
DC Field | Value | |
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dc.title | In vivo antimalarial activity of the beta-carboline alkaloid manzamine A | |
dc.contributor.author | Ang, K.K.H. | |
dc.contributor.author | Holmes, M.J. | |
dc.contributor.author | Higa, T. | |
dc.contributor.author | Hamann, M.T. | |
dc.contributor.author | Kara, U.A.K. | |
dc.date.accessioned | 2014-10-27T08:31:22Z | |
dc.date.available | 2014-10-27T08:31:22Z | |
dc.date.issued | 2000 | |
dc.identifier.citation | Ang, K.K.H., Holmes, M.J., Higa, T., Hamann, M.T., Kara, U.A.K. (2000). In vivo antimalarial activity of the beta-carboline alkaloid manzamine A. Antimicrobial Agents and Chemotherapy 44 (6) : 1645-1649. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.44.6.1645-1649.2000 | |
dc.identifier.issn | 00664804 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/100905 | |
dc.description.abstract | Manzamine A, a β-carboline alkaloid present in several marine sponge species, inhibits the growth of the rodent malaria parasite Plasmodium berghei in vivo. More than 90% of the asexual erythrocytic stages of P. berghei were inhibited after a single intraperitoneal injection of manzamine A into infected mice. A remarkable aspect of manzamine A treatment is its ability to prolong the survival of highly parasitemic mice, with 40% recovery 60 days after a single injection. Oral administration of an oil suspension of manzamine A also produced significant reductions in parasitemia. The plasma manzamine A concentration peaked 4 h after injection and remained high even at 48 h. Morphological changes of P. berghei were observed 1 h after treatment of infected mice. (-)-8-Hydroxymanzamine A also displayed antimalarial activity, whereas manzamine F, a ketone analog of manzamine A, did not. Our results suggest that manzamine A and (-)-8-hydroxymanzamine A are promising new antimalarial agents. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1128/AAC.44.6.1645-1649.2000 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.description.doi | 10.1128/AAC.44.6.1645-1649.2000 | |
dc.description.sourcetitle | Antimicrobial Agents and Chemotherapy | |
dc.description.volume | 44 | |
dc.description.issue | 6 | |
dc.description.page | 1645-1649 | |
dc.description.coden | AMACC | |
dc.identifier.isiut | 000087156100037 | |
Appears in Collections: | Staff Publications |
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