Please use this identifier to cite or link to this item: https://doi.org/10.1128/AAC.44.6.1645-1649.2000
DC FieldValue
dc.titleIn vivo antimalarial activity of the beta-carboline alkaloid manzamine A
dc.contributor.authorAng, K.K.H.
dc.contributor.authorHolmes, M.J.
dc.contributor.authorHiga, T.
dc.contributor.authorHamann, M.T.
dc.contributor.authorKara, U.A.K.
dc.date.accessioned2014-10-27T08:31:22Z
dc.date.available2014-10-27T08:31:22Z
dc.date.issued2000
dc.identifier.citationAng, K.K.H., Holmes, M.J., Higa, T., Hamann, M.T., Kara, U.A.K. (2000). In vivo antimalarial activity of the beta-carboline alkaloid manzamine A. Antimicrobial Agents and Chemotherapy 44 (6) : 1645-1649. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.44.6.1645-1649.2000
dc.identifier.issn00664804
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100905
dc.description.abstractManzamine A, a β-carboline alkaloid present in several marine sponge species, inhibits the growth of the rodent malaria parasite Plasmodium berghei in vivo. More than 90% of the asexual erythrocytic stages of P. berghei were inhibited after a single intraperitoneal injection of manzamine A into infected mice. A remarkable aspect of manzamine A treatment is its ability to prolong the survival of highly parasitemic mice, with 40% recovery 60 days after a single injection. Oral administration of an oil suspension of manzamine A also produced significant reductions in parasitemia. The plasma manzamine A concentration peaked 4 h after injection and remained high even at 48 h. Morphological changes of P. berghei were observed 1 h after treatment of infected mice. (-)-8-Hydroxymanzamine A also displayed antimalarial activity, whereas manzamine F, a ketone analog of manzamine A, did not. Our results suggest that manzamine A and (-)-8-hydroxymanzamine A are promising new antimalarial agents.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1128/AAC.44.6.1645-1649.2000
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1128/AAC.44.6.1645-1649.2000
dc.description.sourcetitleAntimicrobial Agents and Chemotherapy
dc.description.volume44
dc.description.issue6
dc.description.page1645-1649
dc.description.codenAMACC
dc.identifier.isiut000087156100037
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