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|Title:||Immunoglobulin-associated creatine kinase masquerading as macro-creatine kinase type 2 in a statin user||Authors:||Loh, T.P.
Mitochondrial creatine kinase
|Issue Date:||2012||Citation:||Loh, T.P., Ang, Y.H., Neo, S.F., Yin, C., Wong, M.S., Leong, S.M., Saw, S., Sethi, S.K. (2012). Immunoglobulin-associated creatine kinase masquerading as macro-creatine kinase type 2 in a statin user. Internal Medicine 51 (9) : 1061-1064. ScholarBank@NUS Repository. https://doi.org/10.2169/internalmedicine.51.7157||Abstract:||Macro-creatine kinase (CK) is a cause of falsely elevated CK. Macro-CK type 1 is immunoglobulinassociated CK; type 2 is polymeric mitochondrial-CK. An elderly asymptomatic lady had an elevated CK level after receiving statin therapy. Her CK gel electrophoresis analysis demonstrated coexisting macro-CK type 1 and type 2 patterns. Further analysis by immunofixation and mixing this patient's serum with CK control material revealed an IgG-associated macro-CK that mimicked the electrophoretic pattern of macro-CK type 2. This highly unusual discovery suggests the possibility of the misinterpretation of macro-CK type 1 as macro-CK type 2. Falsely elevated CK is still common despite modern laboratory instrumentation and should be investigated. © 2012 The Japanese Society of Internal Medicine.||Source Title:||Internal Medicine||URI:||http://scholarbank.nus.edu.sg/handle/10635/100888||ISSN:||09182918||DOI:||10.2169/internalmedicine.51.7157|
|Appears in Collections:||Staff Publications|
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