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Title: Immunoglobulin-associated creatine kinase masquerading as macro-creatine kinase type 2 in a statin user
Authors: Loh, T.P.
Ang, Y.H.
Neo, S.F.
Yin, C.
Wong, M.S.
Leong, S.M. 
Saw, S.
Sethi, S.K.
Keywords: Creatine kinase
Macro-creatine kinase
Mitochondrial creatine kinase
Issue Date: 2012
Citation: Loh, T.P., Ang, Y.H., Neo, S.F., Yin, C., Wong, M.S., Leong, S.M., Saw, S., Sethi, S.K. (2012). Immunoglobulin-associated creatine kinase masquerading as macro-creatine kinase type 2 in a statin user. Internal Medicine 51 (9) : 1061-1064. ScholarBank@NUS Repository.
Abstract: Macro-creatine kinase (CK) is a cause of falsely elevated CK. Macro-CK type 1 is immunoglobulinassociated CK; type 2 is polymeric mitochondrial-CK. An elderly asymptomatic lady had an elevated CK level after receiving statin therapy. Her CK gel electrophoresis analysis demonstrated coexisting macro-CK type 1 and type 2 patterns. Further analysis by immunofixation and mixing this patient's serum with CK control material revealed an IgG-associated macro-CK that mimicked the electrophoretic pattern of macro-CK type 2. This highly unusual discovery suggests the possibility of the misinterpretation of macro-CK type 1 as macro-CK type 2. Falsely elevated CK is still common despite modern laboratory instrumentation and should be investigated. © 2012 The Japanese Society of Internal Medicine.
Source Title: Internal Medicine
ISSN: 09182918
DOI: 10.2169/internalmedicine.51.7157
Appears in Collections:Staff Publications

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